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- NCIT_C71539 IAO_0000115 "A non-replicating adenovirus 5 (Ad-5, El-deleted) encoding a human Fas-chimera (Fas-c) transgene under the control of a modified murine pre-proendothelin-1 (PPE-1) promoter, with potential anti-angiogenic activity. Upon the administration of ofranergene obadenovec, the modified murine PPE-1 promoter is specifically activated in PPE-1-expressing angiogenic endothelial cells residing in the tumor microvasculature. Subsequently, the Fas-c pro-apoptotic transgene, containing the human tumor necrosis factor (TNF) receptor 1 (TNFR-1/p55) and the signaling domain of Fas, is expressed in angiogenic endothelial cells. Fas-mediated apoptosis is activated via binding of the TNFR-1 receptor with TNF-alpha, which is more abundant in the tumor microenvironment (TME), enhancing specificity and limiting systemic toxicities." @default.
- NCIT_C71539 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71539 NCIT_NHC0 "C71539" @default.
- NCIT_C71539 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71539 NCIT_P107 "Ofranergene Obadenovec" @default.
- NCIT_C71539 NCIT_P108 "Ofranergene Obadenovec" @default.
- NCIT_C71539 NCIT_P208 "CL378317" @default.
- NCIT_C71539 NCIT_P210 "1476737-24-2" @default.
- NCIT_C71539 NCIT_P319 "5Q5PRH05GI" @default.
- NCIT_C71539 NCIT_P322 "CTRP" @default.
- NCIT_C71539 NCIT_P322 "FDA" @default.
- NCIT_C71539 NCIT_P322 "GDC" @default.
- NCIT_C71539 NCIT_P329 "580988" @default.
- NCIT_C71539 NCIT_P330 "580988" @default.
- NCIT_C71539 NCIT_P366 "GT-111" @default.
- NCIT_C71539 NCIT_P375 "Angiogenesis Inhibitor GT-111" @default.
- NCIT_C71539 NCIT_P375 "Ofranergene Obadenovec" @default.
- NCIT_C71539 NCIT_P399 "580988" @default.
- NCIT_C71539 normalizedInformationContent "100" @default.
- NCIT_C71539 referenceCount "1" @default.
- NCIT_C71539 hasExactSynonym "GT-111" @default.
- NCIT_C71539 hasExactSynonym "OFRANERGENE OBADENOVEC" @default.
- NCIT_C71539 hasExactSynonym "Ofranergene Obadenovec" @default.
- NCIT_C71539 hasExactSynonym "VB-111" @default.
- NCIT_C71539 inSubset NCIT_C116977 @default.
- NCIT_C71539 inSubset NCIT_C116978 @default.
- NCIT_C71539 inSubset NCIT_C128784 @default.
- NCIT_C71539 inSubset NCIT_C157711 @default.
- NCIT_C71539 inSubset NCIT_C157712 @default.
- NCIT_C71539 inSubset NCIT_C176424 @default.
- NCIT_C71539 inSubset NCIT_C177537 @default.
- NCIT_C71539 inSubset NCIT_C63923 @default.
- NCIT_C71539 type Class @default.
- NCIT_C71539 isDefinedBy ncit.owl @default.
- NCIT_C71539 label "Ofranergene Obadenovec" @default.
- NCIT_C71539 subClassOf NCIT_C1572 @default.
- NCIT_C71539 subClassOf NCIT_C1742 @default.
- NCIT_C71539 subClassOf NCIT_C1908 @default.
- NCIT_C71539 subClassOf NCIT_C1909 @default.
- NCIT_C71539 subClassOf NCIT_C274 @default.
- NCIT_C71539 subClassOf NCIT_C307 @default.
- NCIT_C71539 subClassOf NCIT_C308 @default.
- NCIT_C71539 subClassOf NCIT_C49146 @default.
- NCIT_C71539 subClassOf NCIT_C71539 @default.
- NCIT_C71539 subClassOf NCIT_C923 @default.
- NCIT_C71539 subClassOf NCIT_C96404 @default.