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- NCIT_C71621 IAO_0000115 "A pipecolinate derivative. Functioning as a modulator of P-glycoprotein (P-gp) and multidrug resistance protein (MRP-1), biricodar restores drug sensitivity to cells expressing P-glycoprotein and MRP1, the cellular efflux pumps that are the major causes in tumor cell resistance to chemotherapeutic agents. This agent binds directly to Pgp and MRP-1 and inhibits efflux pump activity, resulting in increased intracellular accumulation and retention of cytotoxic agents." @default.
- NCIT_C71621 NCIT_A5 NCIT_C1653 @default.
- NCIT_C71621 NCIT_NHC0 "C71621" @default.
- NCIT_C71621 NCIT_P106 "Organic Chemical" @default.
- NCIT_C71621 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71621 NCIT_P108 "Biricodar" @default.
- NCIT_C71621 NCIT_P207 "C0754576" @default.
- NCIT_C71621 NCIT_P210 "159997-94-1" @default.
- NCIT_C71621 NCIT_P319 "3KG76X4KJK" @default.
- NCIT_C71621 NCIT_P322 "FDA" @default.
- NCIT_C71621 NCIT_P350 "C34H41N3O7" @default.
- NCIT_C71621 NCIT_P366 "Biricodar" @default.
- NCIT_C71621 normalizedInformationContent "100" @default.
- NCIT_C71621 referenceCount "1" @default.
- NCIT_C71621 hasExactSynonym "BIRICODAR" @default.
- NCIT_C71621 hasExactSynonym "Biricodar" @default.
- NCIT_C71621 hasExactSynonym "VX-710" @default.
- NCIT_C71621 inSubset NCIT_C63923 @default.
- NCIT_C71621 type Class @default.
- NCIT_C71621 isDefinedBy ncit.owl @default.
- NCIT_C71621 label "Biricodar" @default.
- NCIT_C71621 subClassOf NCIT_C1744 @default.
- NCIT_C71621 subClassOf NCIT_C1908 @default.
- NCIT_C71621 subClassOf NCIT_C1909 @default.
- NCIT_C71621 subClassOf NCIT_C71621 @default.