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- NCIT_C71622 IAO_0000115 "An indolinone derivative and tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells." @default.
- NCIT_C71622 NCIT_A32 NCIT_C1909 @default.
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- NCIT_C71622 NCIT_A7 NCIT_C28496 @default.
- NCIT_C71622 NCIT_NHC0 "C71622" @default.
- NCIT_C71622 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71622 NCIT_P107 "Sunitinib" @default.
- NCIT_C71622 NCIT_P108 "Sunitinib" @default.
- NCIT_C71622 NCIT_P207 "C1176020" @default.
- NCIT_C71622 NCIT_P210 "557795-19-4" @default.
- NCIT_C71622 NCIT_P319 "V99T50803M" @default.
- NCIT_C71622 NCIT_P322 "CTRP" @default.
- NCIT_C71622 NCIT_P322 "FDA" @default.
- NCIT_C71622 NCIT_P322 "GDC" @default.
- NCIT_C71622 NCIT_P325 "A drug used to treat gastrointestinal stromal tumors (GIST) that have not responded to treatment with imatinib mesylate (Gleevec). Sunitinib is also used to treat advanced kidney cancer and is being studied in the treatment of other types of cancer. It is a type of tyrosine kinase inhibitor, a type of vascular endothelial growth factor (VEGF) receptor inhibitor, and a type of angiogenesis inhibitor." @default.
- NCIT_C71622 NCIT_P350 "C22H27FN4O2" @default.
- NCIT_C71622 NCIT_P366 "Sunitinib" @default.
- NCIT_C71622 NCIT_P368 "CHEBI:38940" @default.
- NCIT_C71622 NCIT_P375 "Sunitinib" @default.
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- NCIT_C71622 NCIT_R146 NCIT_C20027 @default.
- NCIT_C71622 NCIT_R146 NCIT_C26548 @default.
- NCIT_C71622 normalizedInformationContent "100" @default.
- NCIT_C71622 referenceCount "1" @default.
- NCIT_C71622 hasExactSynonym "1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-" @default.
- NCIT_C71622 hasExactSynonym "SUNITINIB" @default.
- NCIT_C71622 hasExactSynonym "Sunitinib" @default.
- NCIT_C71622 hasExactSynonym "sunitinib" @default.
- NCIT_C71622 inSubset NCIT_C116977 @default.
- NCIT_C71622 inSubset NCIT_C116978 @default.
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- NCIT_C71622 inSubset NCIT_C63923 @default.
- NCIT_C71622 type Class @default.
- NCIT_C71622 isDefinedBy ncit.owl @default.
- NCIT_C71622 label "Sunitinib" @default.
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- NCIT_C71622 subClassOf NCIT_C71622 @default.
- NCIT_C71622 subClassOf NCIT_C93259 @default.