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- NCIT_C71631 IAO_0000115 "A derivative of folic acid with chemoprotectant, antidote and synergistic activity. Leucovorin does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs, and is converted to a tetrahydrofolate, which is the necessary folate for purine and pyrimidine synthesis. As this agent allows for some purine/pyrimidine synthesis to occur, the toxic effects of folic acid antagonist-type chemotherapeutic drugs are counteracted while still permitting the antitumor activity of the folic acid antagonist through dihydrofolate reductase inhibition. This agent also potentiates the effects of 5-fluorouracil and its derivatives by stabilizing the binding of 5-fluorouracil's converted form fluorodeoxyuridylic acid to its target enzyme thymidylate synthase, thus prolonging drug activity." @default.
- NCIT_C71631 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71631 NCIT_A5 NCIT_C607 @default.
- NCIT_C71631 NCIT_A5 NCIT_C97555 @default.
- NCIT_C71631 NCIT_NHC0 "C71631" @default.
- NCIT_C71631 NCIT_P106 "Organic Chemical" @default.
- NCIT_C71631 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71631 NCIT_P107 "Leucovorin" @default.
- NCIT_C71631 NCIT_P108 "Leucovorin" @default.
- NCIT_C71631 NCIT_P207 "C0023413" @default.
- NCIT_C71631 NCIT_P210 "58-05-9" @default.
- NCIT_C71631 NCIT_P319 "Q573I9DVLP" @default.
- NCIT_C71631 NCIT_P322 "CTRP" @default.
- NCIT_C71631 NCIT_P322 "FDA" @default.
- NCIT_C71631 NCIT_P322 "GDC" @default.
- NCIT_C71631 NCIT_P325 "The active ingredient in a drug used to lessen the toxic effects of substances that block the action of folic acid, especially the anticancer drug methotrexate. Folinic acid is used to treat some types of anemia and is also used with fluorouracil to treat colorectal cancer. It is also being studied in the treatment of other types of cancer and other conditions. Folinic acid is a form of folic acid. It is a type of chemoprotective agent and a type of chemosensitizing agent." @default.
- NCIT_C71631 NCIT_P350 "C20H23N7O7" @default.
- NCIT_C71631 NCIT_P366 "Leucovorin" @default.
- NCIT_C71631 NCIT_P368 "CHEBI:15640" @default.
- NCIT_C71631 NCIT_P375 "Leucovorin" @default.
- NCIT_C71631 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C71631 referenceCount "2" @default.
- NCIT_C71631 hasExactSynonym "5-Formyltetrahydrofolate" @default.
- NCIT_C71631 hasExactSynonym "Folinic acid" @default.
- NCIT_C71631 hasExactSynonym "LEUCOVORIN" @default.
- NCIT_C71631 hasExactSynonym "Leucovorin" @default.
- NCIT_C71631 hasExactSynonym "folinic acid" @default.
- NCIT_C71631 hasExactSynonym "leucovorin" @default.
- NCIT_C71631 inSubset NCIT_C116977 @default.
- NCIT_C71631 inSubset NCIT_C116978 @default.
- NCIT_C71631 inSubset NCIT_C157711 @default.
- NCIT_C71631 inSubset NCIT_C157712 @default.
- NCIT_C71631 inSubset NCIT_C177537 @default.
- NCIT_C71631 inSubset NCIT_C63923 @default.
- NCIT_C71631 type Class @default.
- NCIT_C71631 isDefinedBy ncit.owl @default.
- NCIT_C71631 label "Leucovorin" @default.
- NCIT_C71631 subClassOf NCIT_C1908 @default.
- NCIT_C71631 subClassOf NCIT_C1909 @default.
- NCIT_C71631 subClassOf NCIT_C2078 @default.
- NCIT_C71631 subClassOf NCIT_C2140 @default.
- NCIT_C71631 subClassOf NCIT_C71631 @default.