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- NCIT_C71635 IAO_0000115 "A centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK-receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema." @default.
- NCIT_C71635 NCIT_A5 NCIT_C61086 @default.
- NCIT_C71635 NCIT_NHC0 "C71635" @default.
- NCIT_C71635 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71635 NCIT_P108 "Casopitant" @default.
- NCIT_C71635 NCIT_P207 "C2347566" @default.
- NCIT_C71635 NCIT_P210 "414910-27-3" @default.
- NCIT_C71635 NCIT_P319 "3B03KPM27L" @default.
- NCIT_C71635 NCIT_P322 "FDA" @default.
- NCIT_C71635 NCIT_P329 "586488" @default.
- NCIT_C71635 NCIT_P330 "586488" @default.
- NCIT_C71635 NCIT_P350 "C30H35F7N4O2" @default.
- NCIT_C71635 NCIT_P366 "Casopitant_Base" @default.
- NCIT_C71635 NCIT_P399 "586488" @default.
- NCIT_C71635 normalizedInformationContent "100" @default.
- NCIT_C71635 referenceCount "1" @default.
- NCIT_C71635 hasExactSynonym "CASOPITANT" @default.
- NCIT_C71635 hasExactSynonym "Casopitant" @default.
- NCIT_C71635 hasExactSynonym "GW679769" @default.
- NCIT_C71635 inSubset NCIT_C176424 @default.
- NCIT_C71635 inSubset NCIT_C63923 @default.
- NCIT_C71635 type Class @default.
- NCIT_C71635 isDefinedBy ncit.owl @default.
- NCIT_C71635 label "Casopitant" @default.
- NCIT_C71635 subClassOf NCIT_C1908 @default.
- NCIT_C71635 subClassOf NCIT_C1909 @default.
- NCIT_C71635 subClassOf NCIT_C265 @default.
- NCIT_C71635 subClassOf NCIT_C71635 @default.
- NCIT_C71635 subClassOf NCIT_C78272 @default.