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- NCIT_C71692 IAO_0000115 "A controlled-release, intratumoral paclitaxel formulation in which paclitaxel is incorporated into a thermosensitive, biodegradable triblock copolymer consisting of poly(lactide-co-glycolide) (PLGA) and polyethylene glycol (PEG). Upon intratumoral injection, paclitaxel is released slowly and continuously into tumor tissues from the gelled thermosensitive triblock copolymer over a period of 4 to 6 weeks; in tumor cells, paclitaxel binds to tubulin and inhibits the disassembly-assembly dynamics of microtubules, resulting in cell cycle arrest and cell death. The thermosensitive triblock copolymer component of this formulation transforms from a water-soluble polymer at room temperature to a water-insoluble, biodegradable gel depot at body temperature; intratumoral controlled-release of paclitaxel from the gel minimizes systemic exposure to paclitaxel and the paclitaxel toxicity profile." @default.
- NCIT_C71692 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71692 NCIT_A7 NCIT_C17219 @default.
- NCIT_C71692 NCIT_A7 NCIT_C18115 @default.
- NCIT_C71692 NCIT_NHC0 "C71692" @default.
- NCIT_C71692 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71692 NCIT_P107 "PGLA/PEG Copolymer-Based Paclitaxel" @default.
- NCIT_C71692 NCIT_P108 "PGLA/PEG Copolymer-Based Paclitaxel" @default.
- NCIT_C71692 NCIT_P208 "CL376115" @default.
- NCIT_C71692 NCIT_P322 "CTRP" @default.
- NCIT_C71692 NCIT_P322 "GDC" @default.
- NCIT_C71692 NCIT_P329 "555445" @default.
- NCIT_C71692 NCIT_P330 "555445" @default.
- NCIT_C71692 NCIT_P366 "PGLA_PEG_Copolymer-Based_Paclitaxel" @default.
- NCIT_C71692 NCIT_P375 "PGLA/PEG Copolymer-Based Paclitaxel" @default.
- NCIT_C71692 NCIT_P399 "555445" @default.
- NCIT_C71692 NCIT_R124 NCIT_C17828 @default.
- NCIT_C71692 NCIT_R124 NCIT_C20480 @default.
- NCIT_C71692 NCIT_R124 NCIT_C40795 @default.
- NCIT_C71692 NCIT_R124 NCIT_C40798 @default.
- NCIT_C71692 normalizedInformationContent "100" @default.
- NCIT_C71692 referenceCount "1" @default.
- NCIT_C71692 hasExactSynonym "OncoGel" @default.
- NCIT_C71692 hasExactSynonym "PGLA/PEG Copolymer-Based Paclitaxel" @default.
- NCIT_C71692 inSubset NCIT_C116977 @default.
- NCIT_C71692 inSubset NCIT_C116978 @default.
- NCIT_C71692 inSubset NCIT_C128784 @default.
- NCIT_C71692 inSubset NCIT_C157711 @default.
- NCIT_C71692 inSubset NCIT_C157712 @default.
- NCIT_C71692 inSubset NCIT_C176424 @default.
- NCIT_C71692 inSubset NCIT_C177537 @default.
- NCIT_C71692 type Class @default.
- NCIT_C71692 isDefinedBy ncit.owl @default.
- NCIT_C71692 label "PGLA/PEG Copolymer-Based Paclitaxel" @default.
- NCIT_C71692 subClassOf NCIT_C186664 @default.
- NCIT_C71692 subClassOf NCIT_C1908 @default.
- NCIT_C71692 subClassOf NCIT_C1909 @default.
- NCIT_C71692 subClassOf NCIT_C25974 @default.
- NCIT_C71692 subClassOf NCIT_C273 @default.
- NCIT_C71692 subClassOf NCIT_C274 @default.
- NCIT_C71692 subClassOf NCIT_C61078 @default.
- NCIT_C71692 subClassOf NCIT_C67437 @default.
- NCIT_C71692 subClassOf NCIT_C71692 @default.