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- NCIT_C71704 IAO_0000115 "An orally bioavailable small molecule targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinases in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Voxtalisib inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in susceptible tumor cell populations. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion in response to nutrient and energy deprivation. Accordingly, this agent maybe more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone." @default.
- NCIT_C71704 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71704 NCIT_A7 NCIT_C17270 @default.
- NCIT_C71704 NCIT_NHC0 "C71704" @default.
- NCIT_C71704 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71704 NCIT_P107 "Voxtalisib" @default.
- NCIT_C71704 NCIT_P108 "Voxtalisib" @default.
- NCIT_C71704 NCIT_P207 "C2348352" @default.
- NCIT_C71704 NCIT_P210 "934493-76-2" @default.
- NCIT_C71704 NCIT_P319 "CVL1685GPH" @default.
- NCIT_C71704 NCIT_P322 "CTRP" @default.
- NCIT_C71704 NCIT_P322 "FDA" @default.
- NCIT_C71704 NCIT_P322 "GDC" @default.
- NCIT_C71704 NCIT_P329 "558907" @default.
- NCIT_C71704 NCIT_P330 "558907" @default.
- NCIT_C71704 NCIT_P366 "Dual_Kinase_Inhibitor_XL765" @default.
- NCIT_C71704 NCIT_P375 "Voxtalisib" @default.
- NCIT_C71704 NCIT_P399 "558907" @default.
- NCIT_C71704 normalizedInformationContent "100" @default.
- NCIT_C71704 referenceCount "1" @default.
- NCIT_C71704 hasExactSynonym "SAR-245409" @default.
- NCIT_C71704 hasExactSynonym "SAR245409" @default.
- NCIT_C71704 hasExactSynonym "VOXTALISIB" @default.
- NCIT_C71704 hasExactSynonym "Voxtalisib" @default.
- NCIT_C71704 hasExactSynonym "XL-765" @default.
- NCIT_C71704 hasExactSynonym "XL765" @default.
- NCIT_C71704 inSubset NCIT_C116977 @default.
- NCIT_C71704 inSubset NCIT_C116978 @default.
- NCIT_C71704 inSubset NCIT_C128784 @default.
- NCIT_C71704 inSubset NCIT_C157711 @default.
- NCIT_C71704 inSubset NCIT_C157712 @default.
- NCIT_C71704 inSubset NCIT_C176424 @default.
- NCIT_C71704 inSubset NCIT_C177537 @default.
- NCIT_C71704 inSubset NCIT_C63923 @default.
- NCIT_C71704 type Class @default.
- NCIT_C71704 isDefinedBy ncit.owl @default.
- NCIT_C71704 label "Voxtalisib" @default.
- NCIT_C71704 subClassOf NCIT_C129824 @default.
- NCIT_C71704 subClassOf NCIT_C129825 @default.
- NCIT_C71704 subClassOf NCIT_C1404 @default.
- NCIT_C71704 subClassOf NCIT_C163758 @default.
- NCIT_C71704 subClassOf NCIT_C1742 @default.
- NCIT_C71704 subClassOf NCIT_C1908 @default.
- NCIT_C71704 subClassOf NCIT_C1909 @default.
- NCIT_C71704 subClassOf NCIT_C2152 @default.
- NCIT_C71704 subClassOf NCIT_C2189 @default.
- NCIT_C71704 subClassOf NCIT_C274 @default.
- NCIT_C71704 subClassOf NCIT_C471 @default.
- NCIT_C71704 subClassOf NCIT_C71704 @default.