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- NCIT_C71705 IAO_0000115 "An orally bioavailable small molecule, targeting the class I phosphatidylinositol 3 kinase (PI3K) family of lipid kinases, with potential antineoplastic activity. Pilaralisib reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K signaling pathway; this may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents including genotoxic agents and receptor tyrosine kinase inhibitors." @default.
- NCIT_C71705 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71705 NCIT_A7 NCIT_C17270 @default.
- NCIT_C71705 NCIT_NHC0 "C71705" @default.
- NCIT_C71705 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71705 NCIT_P107 "Pilaralisib" @default.
- NCIT_C71705 NCIT_P108 "Pilaralisib" @default.
- NCIT_C71705 NCIT_P207 "C2347424" @default.
- NCIT_C71705 NCIT_P210 "934526-89-3" @default.
- NCIT_C71705 NCIT_P319 "60ES45KTMK" @default.
- NCIT_C71705 NCIT_P322 "CTRP" @default.
- NCIT_C71705 NCIT_P322 "FDA" @default.
- NCIT_C71705 NCIT_P322 "GDC" @default.
- NCIT_C71705 NCIT_P329 "558909" @default.
- NCIT_C71705 NCIT_P330 "558909" @default.
- NCIT_C71705 NCIT_P366 "PI3K_Family_Kinase_Inhibitor_XL147" @default.
- NCIT_C71705 NCIT_P375 "Pilaralisib" @default.
- NCIT_C71705 NCIT_P399 "558909" @default.
- NCIT_C71705 normalizedInformationContent "100" @default.
- NCIT_C71705 referenceCount "1" @default.
- NCIT_C71705 hasExactSynonym "2-Amino-N-(3-(N-(3-((2-chloro-5-methoxyphenyl)amino)quinoxalin-2-yl)sulfamoyl)phenyl)-2-methylpropanamide" @default.
- NCIT_C71705 hasExactSynonym "PILARALISIB" @default.
- NCIT_C71705 hasExactSynonym "Pilaralisib" @default.
- NCIT_C71705 hasExactSynonym "SAR245408" @default.
- NCIT_C71705 hasExactSynonym "XL 147" @default.
- NCIT_C71705 hasExactSynonym "XL-147" @default.
- NCIT_C71705 hasExactSynonym "XL147" @default.
- NCIT_C71705 inSubset NCIT_C116977 @default.
- NCIT_C71705 inSubset NCIT_C116978 @default.
- NCIT_C71705 inSubset NCIT_C128784 @default.
- NCIT_C71705 inSubset NCIT_C157711 @default.
- NCIT_C71705 inSubset NCIT_C157712 @default.
- NCIT_C71705 inSubset NCIT_C176424 @default.
- NCIT_C71705 inSubset NCIT_C177537 @default.
- NCIT_C71705 inSubset NCIT_C63923 @default.
- NCIT_C71705 type Class @default.
- NCIT_C71705 isDefinedBy ncit.owl @default.
- NCIT_C71705 label "Pilaralisib" @default.
- NCIT_C71705 subClassOf NCIT_C129824 @default.
- NCIT_C71705 subClassOf NCIT_C129825 @default.
- NCIT_C71705 subClassOf NCIT_C1404 @default.
- NCIT_C71705 subClassOf NCIT_C163758 @default.
- NCIT_C71705 subClassOf NCIT_C1742 @default.
- NCIT_C71705 subClassOf NCIT_C1908 @default.
- NCIT_C71705 subClassOf NCIT_C1909 @default.
- NCIT_C71705 subClassOf NCIT_C2152 @default.
- NCIT_C71705 subClassOf NCIT_C2189 @default.
- NCIT_C71705 subClassOf NCIT_C274 @default.
- NCIT_C71705 subClassOf NCIT_C471 @default.
- NCIT_C71705 subClassOf NCIT_C71705 @default.