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- NCIT_C71708 IAO_0000115 "An orally available, small-molecule histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Pracinostat inhibits HDACs, which may result in the accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; the tumor suppressor protein-mediated inhibition of tumor cell division; and, finally, the induction of tumor cell apoptosis. This agent may possess improved metabolic, pharmacokinetic and pharmacological properties compared to other HDAC inhibitors." @default.
- NCIT_C71708 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71708 NCIT_A7 NCIT_C16682 @default.
- NCIT_C71708 NCIT_NHC0 "C71708" @default.
- NCIT_C71708 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71708 NCIT_P107 "Pracinostat" @default.
- NCIT_C71708 NCIT_P108 "Pracinostat" @default.
- NCIT_C71708 NCIT_P207 "C3467801" @default.
- NCIT_C71708 NCIT_P210 "929016-96-6" @default.
- NCIT_C71708 NCIT_P319 "GPO2JN4UON" @default.
- NCIT_C71708 NCIT_P322 "CTRP" @default.
- NCIT_C71708 NCIT_P322 "FDA" @default.
- NCIT_C71708 NCIT_P322 "GDC" @default.
- NCIT_C71708 NCIT_P325 "A substance being studied in the treatment of several types of cancer. SB939 blocks the action of an enzyme called histone deacetylase (HDAC) and may stop tumor cells from dividing. It is a type of HDAC inhibitor." @default.
- NCIT_C71708 NCIT_P329 "559644" @default.
- NCIT_C71708 NCIT_P330 "559644" @default.
- NCIT_C71708 NCIT_P350 "C20H30N4O2" @default.
- NCIT_C71708 NCIT_P366 "HDAC_Inhibitor_SB939" @default.
- NCIT_C71708 NCIT_P375 "Pracinostat" @default.
- NCIT_C71708 NCIT_P399 "559644" @default.
- NCIT_C71708 normalizedInformationContent "100" @default.
- NCIT_C71708 referenceCount "1" @default.
- NCIT_C71708 hasExactSynonym "2-propenamide, 3-(2-butyl-1-(2-(diethylamino)ethyl)-1h-benzimidazol-5-yl)-N-hydroxy-, (2E)-" @default.
- NCIT_C71708 hasExactSynonym "HDAC Inhibitor SB939" @default.
- NCIT_C71708 hasExactSynonym "PRACINOSTAT" @default.
- NCIT_C71708 hasExactSynonym "Pracinostat" @default.
- NCIT_C71708 hasExactSynonym "SB939" @default.
- NCIT_C71708 hasExactSynonym "kaempferol 3-o-beta-d-(6-E-P-coumaroylglucoside)" @default.
- NCIT_C71708 inSubset NCIT_C116977 @default.
- NCIT_C71708 inSubset NCIT_C116978 @default.
- NCIT_C71708 inSubset NCIT_C128784 @default.
- NCIT_C71708 inSubset NCIT_C157711 @default.
- NCIT_C71708 inSubset NCIT_C157712 @default.
- NCIT_C71708 inSubset NCIT_C176424 @default.
- NCIT_C71708 inSubset NCIT_C177537 @default.
- NCIT_C71708 inSubset NCIT_C63923 @default.
- NCIT_C71708 type Class @default.
- NCIT_C71708 isDefinedBy ncit.owl @default.
- NCIT_C71708 label "Pracinostat" @default.
- NCIT_C71708 subClassOf NCIT_C163758 @default.
- NCIT_C71708 subClassOf NCIT_C1908 @default.
- NCIT_C71708 subClassOf NCIT_C1909 @default.
- NCIT_C71708 subClassOf NCIT_C1946 @default.
- NCIT_C71708 subClassOf NCIT_C274 @default.
- NCIT_C71708 subClassOf NCIT_C471 @default.
- NCIT_C71708 subClassOf NCIT_C71708 @default.