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- NCIT_C71711 IAO_0000115 "An aminofurazan-derived inhibitor of Akt kinases with potential antineoplastic activity. Pan-AKT kinase inhibitor GSK-690693 binds to and inhibits Akt kinases 1, 2, and 3, which may result in the inhibition of protein phosphorylation events downstream from Akt kinases in the PI3K/Akt signaling pathway, and, subsequently, the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In addition, this agent may inhibit other protein kinases including protein kinase C (PKC) and protein kinase A (PKA). As serine/threonine protein kinases which are involved in a number of biological processes, AKT kinases promote cell survival by inhibiting apoptosis and are required for glucose transport." @default.
- NCIT_C71711 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71711 NCIT_A7 NCIT_C41625 @default.
- NCIT_C71711 NCIT_NHC0 "C71711" @default.
- NCIT_C71711 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71711 NCIT_P107 "Pan-AKT Kinase Inhibitor GSK690693" @default.
- NCIT_C71711 NCIT_P108 "Pan-AKT Kinase Inhibitor GSK690693" @default.
- NCIT_C71711 NCIT_P207 "C2347443" @default.
- NCIT_C71711 NCIT_P210 "937174-76-0" @default.
- NCIT_C71711 NCIT_P319 "GWH480321B" @default.
- NCIT_C71711 NCIT_P322 "CTRP" @default.
- NCIT_C71711 NCIT_P322 "FDA" @default.
- NCIT_C71711 NCIT_P322 "GDC" @default.
- NCIT_C71711 NCIT_P329 "560189" @default.
- NCIT_C71711 NCIT_P330 "560189" @default.
- NCIT_C71711 NCIT_P366 "Pan-AKT_Inhibitor_GSK-690693" @default.
- NCIT_C71711 NCIT_P375 "Pan-AKT Kinase Inhibitor GSK690693" @default.
- NCIT_C71711 NCIT_P399 "560189" @default.
- NCIT_C71711 normalizedInformationContent "100" @default.
- NCIT_C71711 referenceCount "1" @default.
- NCIT_C71711 hasExactSynonym "GSK-690693" @default.
- NCIT_C71711 hasExactSynonym "GSK690693" @default.
- NCIT_C71711 hasExactSynonym "Pan-AKT Kinase Inhibitor GSK690693" @default.
- NCIT_C71711 inSubset NCIT_C116977 @default.
- NCIT_C71711 inSubset NCIT_C116978 @default.
- NCIT_C71711 inSubset NCIT_C128784 @default.
- NCIT_C71711 inSubset NCIT_C157711 @default.
- NCIT_C71711 inSubset NCIT_C157712 @default.
- NCIT_C71711 inSubset NCIT_C176424 @default.
- NCIT_C71711 inSubset NCIT_C177537 @default.
- NCIT_C71711 inSubset NCIT_C63923 @default.
- NCIT_C71711 type Class @default.
- NCIT_C71711 isDefinedBy ncit.owl @default.
- NCIT_C71711 label "Pan-AKT Kinase Inhibitor GSK690693" @default.
- NCIT_C71711 subClassOf NCIT_C129824 @default.
- NCIT_C71711 subClassOf NCIT_C129825 @default.
- NCIT_C71711 subClassOf NCIT_C1404 @default.
- NCIT_C71711 subClassOf NCIT_C155764 @default.
- NCIT_C71711 subClassOf NCIT_C1742 @default.
- NCIT_C71711 subClassOf NCIT_C1908 @default.
- NCIT_C71711 subClassOf NCIT_C1909 @default.
- NCIT_C71711 subClassOf NCIT_C2189 @default.
- NCIT_C71711 subClassOf NCIT_C274 @default.
- NCIT_C71711 subClassOf NCIT_C471 @default.
- NCIT_C71711 subClassOf NCIT_C61074 @default.
- NCIT_C71711 subClassOf NCIT_C71711 @default.