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- NCIT_C71716 IAO_0000115 "An orally bioavailable hydroxymate inhibitor of histone deacetylase (HDAC) with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. Givinostat inhibits class I and class II HDACs, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. At low, nonapoptotic concentrations, this agent inhibits the production of pro-inflammatory cytokines such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-6 and interferon-gamma. Givinostat has also been shown to activate the intrinsic apoptotic pathway, inducing apoptosis in hepatoma cells and leukemic cells. This agent may also exhibit anti-angiogenic activity, inhibiting the production of angiogenic factors such as IL-6 and vascular endothelial cell growth factor (VEGF) by bone marrow stromal cells." @default.
- NCIT_C71716 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71716 NCIT_NHC0 "C71716" @default.
- NCIT_C71716 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71716 NCIT_P108 "Givinostat" @default.
- NCIT_C71716 NCIT_P207 "C2987670" @default.
- NCIT_C71716 NCIT_P210 "497833-27-9" @default.
- NCIT_C71716 NCIT_P319 "5P60F84FBH" @default.
- NCIT_C71716 NCIT_P322 "FDA" @default.
- NCIT_C71716 NCIT_P322 "GDC" @default.
- NCIT_C71716 NCIT_P329 "560751" @default.
- NCIT_C71716 NCIT_P330 "560751" @default.
- NCIT_C71716 NCIT_P350 "C24H27N3O4" @default.
- NCIT_C71716 NCIT_P366 "HDAC_Inhibitor_ITF2357" @default.
- NCIT_C71716 NCIT_P375 "Givinostat" @default.
- NCIT_C71716 NCIT_P399 "560751" @default.
- NCIT_C71716 normalizedInformationContent "100" @default.
- NCIT_C71716 referenceCount "1" @default.
- NCIT_C71716 hasExactSynonym "GIVINOSTAT" @default.
- NCIT_C71716 hasExactSynonym "Gavinostat" @default.
- NCIT_C71716 hasExactSynonym "Givinostat" @default.
- NCIT_C71716 hasExactSynonym "ITF2357" @default.
- NCIT_C71716 inSubset NCIT_C128784 @default.
- NCIT_C71716 inSubset NCIT_C157711 @default.
- NCIT_C71716 inSubset NCIT_C157712 @default.
- NCIT_C71716 inSubset NCIT_C176424 @default.
- NCIT_C71716 inSubset NCIT_C177537 @default.
- NCIT_C71716 inSubset NCIT_C63923 @default.
- NCIT_C71716 type Class @default.
- NCIT_C71716 isDefinedBy ncit.owl @default.
- NCIT_C71716 label "Givinostat" @default.
- NCIT_C71716 subClassOf NCIT_C163758 @default.
- NCIT_C71716 subClassOf NCIT_C1742 @default.
- NCIT_C71716 subClassOf NCIT_C1908 @default.
- NCIT_C71716 subClassOf NCIT_C1909 @default.
- NCIT_C71716 subClassOf NCIT_C1946 @default.
- NCIT_C71716 subClassOf NCIT_C274 @default.
- NCIT_C71716 subClassOf NCIT_C471 @default.
- NCIT_C71716 subClassOf NCIT_C71716 @default.