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- NCIT_C71717 IAO_0000115 "A second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Alisertib binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers." @default.
- NCIT_C71717 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71717 NCIT_A5 NCIT_C142912 @default.
- NCIT_C71717 NCIT_A7 NCIT_C30006 @default.
- NCIT_C71717 NCIT_NHC0 "C71717" @default.
- NCIT_C71717 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71717 NCIT_P107 "Alisertib" @default.
- NCIT_C71717 NCIT_P108 "Alisertib" @default.
- NCIT_C71717 NCIT_P207 "C2346875" @default.
- NCIT_C71717 NCIT_P210 "1028486-01-2" @default.
- NCIT_C71717 NCIT_P319 "T66ES73M18" @default.
- NCIT_C71717 NCIT_P322 "CTRP" @default.
- NCIT_C71717 NCIT_P322 "FDA" @default.
- NCIT_C71717 NCIT_P322 "GDC" @default.
- NCIT_C71717 NCIT_P329 "561286" @default.
- NCIT_C71717 NCIT_P330 "561286" @default.
- NCIT_C71717 NCIT_P350 "C27H20ClFN4O4" @default.
- NCIT_C71717 NCIT_P366 "Aurora_A_Kinase_Inhibitor_MLN8237" @default.
- NCIT_C71717 NCIT_P375 "Alisertib" @default.
- NCIT_C71717 NCIT_P399 "561286" @default.
- NCIT_C71717 NCIT_R146 NCIT_C16554 @default.
- NCIT_C71717 NCIT_R146 NCIT_C16984 @default.
- NCIT_C71717 NCIT_R146 NCIT_C17018 @default.
- NCIT_C71717 NCIT_R146 NCIT_C17021 @default.
- NCIT_C71717 NCIT_R146 NCIT_C17210 @default.
- NCIT_C71717 NCIT_R146 NCIT_C17325 @default.
- NCIT_C71717 NCIT_R146 NCIT_C20027 @default.
- NCIT_C71717 NCIT_R146 NCIT_C26548 @default.
- NCIT_C71717 NCIT_R146 NCIT_C30006 @default.
- NCIT_C71717 normalizedInformationContent "100" @default.
- NCIT_C71717 referenceCount "1" @default.
- NCIT_C71717 hasExactSynonym "ALISERTIB" @default.
- NCIT_C71717 hasExactSynonym "Alisertib" @default.
- NCIT_C71717 hasExactSynonym "Aurora A Kinase Inhibitor MLN8237" @default.
- NCIT_C71717 hasExactSynonym "Benzoic Acid, 4-((9-Chloro-7-(2-Fluoro-6-Methoxyphenyl)-5H-Pyrimido(5,4-d)(2)Benzazepin-2-yl)Amino)-2-Methoxy-" @default.
- NCIT_C71717 hasExactSynonym "MLN-8237" @default.
- NCIT_C71717 hasExactSynonym "MLN8237" @default.
- NCIT_C71717 inSubset NCIT_C116977 @default.
- NCIT_C71717 inSubset NCIT_C116978 @default.
- NCIT_C71717 inSubset NCIT_C128784 @default.
- NCIT_C71717 inSubset NCIT_C157711 @default.
- NCIT_C71717 inSubset NCIT_C157712 @default.
- NCIT_C71717 inSubset NCIT_C176424 @default.
- NCIT_C71717 inSubset NCIT_C177537 @default.
- NCIT_C71717 inSubset NCIT_C63923 @default.
- NCIT_C71717 type Class @default.
- NCIT_C71717 isDefinedBy ncit.owl @default.
- NCIT_C71717 label "Alisertib" @default.
- NCIT_C71717 subClassOf NCIT_C129824 @default.
- NCIT_C71717 subClassOf NCIT_C129825 @default.
- NCIT_C71717 subClassOf NCIT_C1404 @default.
- NCIT_C71717 subClassOf NCIT_C1908 @default.
- NCIT_C71717 subClassOf NCIT_C1909 @default.
- NCIT_C71717 subClassOf NCIT_C2189 @default.
- NCIT_C71717 subClassOf NCIT_C274 @default.
- NCIT_C71717 subClassOf NCIT_C471 @default.
- NCIT_C71717 subClassOf NCIT_C61074 @default.
- NCIT_C71717 subClassOf NCIT_C62556 @default.
- NCIT_C71717 subClassOf NCIT_C71717 @default.