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- NCIT_C71718 IAO_0000115 "A long-acting, pegylated recombinant variant of human granulocyte colony-stimulating factor (G-CSF) with immunomodulating activity. Pegylated granulocyte colony stimulating factor MAXY-G34 contains multiple non-naturally occurring lysines that have been introduced into alpha helixes of wild type human G-CSF as pegylation sites; other naturally occurring lysine residues have been removed to prevent pegylation and the variant G-CSF is pegylated with methoxypolyethylene glycol succinimidyl propionate (mPEG SPA) at three amino acid residues. Similar to endogenous G-CSF, this agent binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. A difference in the degree of pegylation may account for the extended half-life of this agent compared to pegfilgrastim which is pegylated at only one amino acid residue." @default.
- NCIT_C71718 NCIT_NHC0 "C71718" @default.
- NCIT_C71718 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71718 NCIT_P108 "Pegylated Granulocyte Colony Stimulating Factor MAXY-G34" @default.
- NCIT_C71718 NCIT_P207 "C2347460" @default.
- NCIT_C71718 NCIT_P329 "561025" @default.
- NCIT_C71718 NCIT_P330 "561025" @default.
- NCIT_C71718 NCIT_P366 "Pegylated_G-SCF_MAXY-G34" @default.
- NCIT_C71718 NCIT_P399 "561025" @default.
- NCIT_C71718 NCIT_R124 NCIT_C17828 @default.
- NCIT_C71718 NCIT_R124 NCIT_C18992 @default.
- NCIT_C71718 NCIT_R124 NCIT_C19143 @default.
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- NCIT_C71718 NCIT_R124 NCIT_C40702 @default.
- NCIT_C71718 NCIT_R124 NCIT_C45547 @default.
- NCIT_C71718 NCIT_R125 NCIT_C16399 @default.
- NCIT_C71718 NCIT_R125 NCIT_C17828 @default.
- NCIT_C71718 NCIT_R125 NCIT_C18081 @default.
- NCIT_C71718 NCIT_R125 NCIT_C18992 @default.
- NCIT_C71718 NCIT_R125 NCIT_C19143 @default.
- NCIT_C71718 NCIT_R125 NCIT_C20480 @default.
- NCIT_C71718 NCIT_R125 NCIT_C20863 @default.
- NCIT_C71718 NCIT_R125 NCIT_C21124 @default.
- NCIT_C71718 NCIT_R125 NCIT_C40702 @default.
- NCIT_C71718 NCIT_R125 NCIT_C40738 @default.
- NCIT_C71718 NCIT_R146 NCIT_C21176 @default.
- NCIT_C71718 NCIT_R146 NCIT_C26548 @default.
- NCIT_C71718 NCIT_R146 NCIT_C38991 @default.
- NCIT_C71718 NCIT_R72 NCIT_C12219 @default.
- NCIT_C71718 NCIT_R72 NCIT_C12508 @default.
- NCIT_C71718 NCIT_R72 NCIT_C12551 @default.
- NCIT_C71718 NCIT_R72 NCIT_C12662 @default.
- NCIT_C71718 NCIT_R72 NCIT_C21599 @default.
- NCIT_C71718 NCIT_R72 NCIT_C32725 @default.
- NCIT_C71718 normalizedInformationContent "100" @default.
- NCIT_C71718 referenceCount "1" @default.
- NCIT_C71718 hasExactSynonym "MAXY-G34" @default.
- NCIT_C71718 hasExactSynonym "PEG-GCSF MAXY-G34" @default.
- NCIT_C71718 hasExactSynonym "Pegylated Granulocyte Colony Stimulating Factor MAXY-G34" @default.
- NCIT_C71718 inSubset NCIT_C176424 @default.
- NCIT_C71718 type Class @default.
- NCIT_C71718 isDefinedBy ncit.owl @default.
- NCIT_C71718 label "Pegylated Granulocyte Colony Stimulating Factor MAXY-G34" @default.
- NCIT_C71718 subClassOf NCIT_C1283 @default.
- NCIT_C71718 subClassOf NCIT_C1287 @default.
- NCIT_C71718 subClassOf NCIT_C1908 @default.
- NCIT_C71718 subClassOf NCIT_C1909 @default.
- NCIT_C71718 subClassOf NCIT_C2395 @default.
- NCIT_C71718 subClassOf NCIT_C307 @default.
- NCIT_C71718 subClassOf NCIT_C308 @default.
- NCIT_C71718 subClassOf NCIT_C387 @default.
- NCIT_C71718 subClassOf NCIT_C530 @default.
- NCIT_C71718 subClassOf NCIT_C71718 @default.