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- NCIT_C71721 IAO_0000115 "A small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks." @default.
- NCIT_C71721 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71721 NCIT_NHC0 "C71721" @default.
- NCIT_C71721 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71721 NCIT_P107 "Olaparib" @default.
- NCIT_C71721 NCIT_P108 "Olaparib" @default.
- NCIT_C71721 NCIT_P207 "C2316164" @default.
- NCIT_C71721 NCIT_P210 "763113-22-0" @default.
- NCIT_C71721 NCIT_P302 "adult patients with deleterious or suspected deleterious germline or somatic homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC), who have progressed following prior treatment with enzalutamide or abiraterone." @default.
- NCIT_C71721 NCIT_P302 "deleterious or suspected deleterious germline or somatic BRCA-mutated (gBRCAm or sBRCAm) advanced epithelial ovarian, fallopian tube or primary peritoneal cancer; deleterious or suspected deleterious germline BRCA-mutated (gBRCAm), HER2-negative metastatic breast cancer" @default.
- NCIT_C71721 NCIT_P319 "WOH1JD9AR8" @default.
- NCIT_C71721 NCIT_P322 "CTRP" @default.
- NCIT_C71721 NCIT_P322 "FDA" @default.
- NCIT_C71721 NCIT_P322 "GDC" @default.
- NCIT_C71721 NCIT_P325 "A substance being studied in the treatment of breast, ovarian, and prostate cancers caused by mutations (changes) in the BRCA1 and BRCA2 genes. It is also being studied in the treatment of other types of cancer. It blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. AZD2281 may cause cancer cells to die. It is a type of targeted therapy agent and a type of poly (ADP-ribose) polymerase inhibitor." @default.
- NCIT_C71721 NCIT_P329 "560191" @default.
- NCIT_C71721 NCIT_P330 "560191" @default.
- NCIT_C71721 NCIT_P350 "C24H23FN4O3" @default.
- NCIT_C71721 NCIT_P366 "PARP_Inhibitor_AZD2281" @default.
- NCIT_C71721 NCIT_P375 "Olaparib" @default.
- NCIT_C71721 NCIT_P399 "560191" @default.
- NCIT_C71721 NCIT_R146 NCIT_C104101 @default.
- NCIT_C71721 NCIT_R146 NCIT_C16554 @default.
- NCIT_C71721 NCIT_R146 NCIT_C17021 @default.
- NCIT_C71721 NCIT_R146 NCIT_C17210 @default.
- NCIT_C71721 NCIT_R146 NCIT_C17434 @default.
- NCIT_C71721 NCIT_R146 NCIT_C20027 @default.
- NCIT_C71721 NCIT_R146 NCIT_C21170 @default.
- NCIT_C71721 NCIT_R146 NCIT_C26548 @default.
- NCIT_C71721 NCIT_R146 NCIT_C48215 @default.
- NCIT_C71721 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C71721 referenceCount "3" @default.
- NCIT_C71721 hasExactSynonym "AZD 2281" @default.
- NCIT_C71721 hasExactSynonym "AZD-2281" @default.
- NCIT_C71721 hasExactSynonym "AZD2281" @default.
- NCIT_C71721 hasExactSynonym "KU-0059436" @default.
- NCIT_C71721 hasExactSynonym "Lynparza" @default.
- NCIT_C71721 hasExactSynonym "OLAPARIB" @default.
- NCIT_C71721 hasExactSynonym "Olanib" @default.
- NCIT_C71721 hasExactSynonym "Olaparib" @default.
- NCIT_C71721 hasExactSynonym "Olaparix" @default.
- NCIT_C71721 hasExactSynonym "PARP Inhibitor AZD2281" @default.
- NCIT_C71721 hasExactSynonym "PARP inhibitor AZD2281" @default.
- NCIT_C71721 hasExactSynonym "olaparib" @default.
- NCIT_C71721 inSubset NCIT_C116977 @default.
- NCIT_C71721 inSubset NCIT_C116978 @default.
- NCIT_C71721 inSubset NCIT_C128784 @default.
- NCIT_C71721 inSubset NCIT_C157711 @default.
- NCIT_C71721 inSubset NCIT_C157712 @default.
- NCIT_C71721 inSubset NCIT_C176424 @default.
- NCIT_C71721 inSubset NCIT_C177537 @default.
- NCIT_C71721 inSubset NCIT_C63923 @default.
- NCIT_C71721 type Class @default.
- NCIT_C71721 isDefinedBy ncit.owl @default.
- NCIT_C71721 label "Olaparib" @default.
- NCIT_C71721 subClassOf NCIT_C163758 @default.
- NCIT_C71721 subClassOf NCIT_C1908 @default.
- NCIT_C71721 subClassOf NCIT_C1909 @default.
- NCIT_C71721 subClassOf NCIT_C274 @default.
- NCIT_C71721 subClassOf NCIT_C471 @default.
- NCIT_C71721 subClassOf NCIT_C62554 @default.
- NCIT_C71721 subClassOf NCIT_C71721 @default.