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- NCIT_C71722 IAO_0000115 "A hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM) conjugated with 2-nitroimidazole, with potential antineoplastic activity. When exposed to hypoxic conditions, such as those found in hypoxic tumors, the 2-nitroimidazole moiety of evofosfamide is reduced. This releases the DNA-alkylating Br-IPM moiety, which introduces intra- and inter-strand DNA crosslinks in nearby cells; the crosslinks inhibit both DNA replication and cell division, and may lead to apoptosis of cells in the tumor. The inactive form of the prodrug is stable under normoxic conditions, which may limit systemic toxicity." @default.
- NCIT_C71722 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71722 NCIT_NHC0 "C71722" @default.
- NCIT_C71722 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71722 NCIT_P107 "Evofosfamide" @default.
- NCIT_C71722 NCIT_P108 "Evofosfamide" @default.
- NCIT_C71722 NCIT_P207 "C2348906" @default.
- NCIT_C71722 NCIT_P210 "918633-87-1" @default.
- NCIT_C71722 NCIT_P319 "8A9RZ3HN8W" @default.
- NCIT_C71722 NCIT_P322 "CTRP" @default.
- NCIT_C71722 NCIT_P322 "FDA" @default.
- NCIT_C71722 NCIT_P322 "GDC" @default.
- NCIT_C71722 NCIT_P329 "560194" @default.
- NCIT_C71722 NCIT_P330 "560194" @default.
- NCIT_C71722 NCIT_P366 "HAP_TH-302" @default.
- NCIT_C71722 NCIT_P375 "Evofosfamide" @default.
- NCIT_C71722 NCIT_P399 "560194" @default.
- NCIT_C71722 normalizedInformationContent "100" @default.
- NCIT_C71722 referenceCount "1" @default.
- NCIT_C71722 hasExactSynonym "EVOFOSFAMIDE" @default.
- NCIT_C71722 hasExactSynonym "Evofosfamide" @default.
- NCIT_C71722 hasExactSynonym "HAP TH-302" @default.
- NCIT_C71722 hasExactSynonym "Hypoxia-Activated Prodrug TH-302" @default.
- NCIT_C71722 hasExactSynonym "Phosphorodiamidic Acid, N,N'-bis(2-bromoethyl)-, (1-methyl-2-nitro-1H-imidazol-5-yl)methyl Ester" @default.
- NCIT_C71722 hasExactSynonym "TH-302" @default.
- NCIT_C71722 inSubset NCIT_C116977 @default.
- NCIT_C71722 inSubset NCIT_C116978 @default.
- NCIT_C71722 inSubset NCIT_C128784 @default.
- NCIT_C71722 inSubset NCIT_C157711 @default.
- NCIT_C71722 inSubset NCIT_C157712 @default.
- NCIT_C71722 inSubset NCIT_C176424 @default.
- NCIT_C71722 inSubset NCIT_C177537 @default.
- NCIT_C71722 inSubset NCIT_C63923 @default.
- NCIT_C71722 type Class @default.
- NCIT_C71722 isDefinedBy ncit.owl @default.
- NCIT_C71722 label "Evofosfamide" @default.
- NCIT_C71722 subClassOf NCIT_C186664 @default.
- NCIT_C71722 subClassOf NCIT_C1908 @default.
- NCIT_C71722 subClassOf NCIT_C1909 @default.
- NCIT_C71722 subClassOf NCIT_C25760 @default.
- NCIT_C71722 subClassOf NCIT_C274 @default.
- NCIT_C71722 subClassOf NCIT_C2842 @default.
- NCIT_C71722 subClassOf NCIT_C71722 @default.