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- NCIT_C71726 IAO_0000115 "A fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis." @default.
- NCIT_C71726 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71726 NCIT_NHC0 "C71726" @default.
- NCIT_C71726 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71726 NCIT_P107 "Quarfloxin" @default.
- NCIT_C71726 NCIT_P108 "Quarfloxin" @default.
- NCIT_C71726 NCIT_P207 "C2713025" @default.
- NCIT_C71726 NCIT_P210 "865311-47-3" @default.
- NCIT_C71726 NCIT_P319 "8M31J5031Q" @default.
- NCIT_C71726 NCIT_P322 "CTRP" @default.
- NCIT_C71726 NCIT_P322 "FDA" @default.
- NCIT_C71726 NCIT_P322 "GDC" @default.
- NCIT_C71726 NCIT_P329 "558903" @default.
- NCIT_C71726 NCIT_P330 "558903" @default.
- NCIT_C71726 NCIT_P350 "C35H33FN6O3" @default.
- NCIT_C71726 NCIT_P366 "Quarfloxacin" @default.
- NCIT_C71726 NCIT_P375 "Quarfloxin" @default.
- NCIT_C71726 NCIT_P399 "558903" @default.
- NCIT_C71726 normalizedInformationContent "100" @default.
- NCIT_C71726 referenceCount "1" @default.
- NCIT_C71726 hasExactSynonym "3H-Benzo(b)pyrido(3,2,1-kl)phenoxazine-2-carboxamide, 5-fluoro-N-(2-((2S)- 1-methyl-2-pyrrolidinyl)ethyl)-3-oxo-6-(3-pyrazinyl-1-pyrrolidinyl)-" @default.
- NCIT_C71726 hasExactSynonym "5-Fluoro-N-(2-((2S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-(3-(pyrazin-2- yl)pyrrolidin-1-yl)-3H-benzo(b)pyrido(3,2,1-kl)phenoxazine-2-carboxamide" @default.
- NCIT_C71726 hasExactSynonym "CX-3543" @default.
- NCIT_C71726 hasExactSynonym "QUARFLOXIN" @default.
- NCIT_C71726 hasExactSynonym "Quarfloxacin" @default.
- NCIT_C71726 hasExactSynonym "Quarfloxin" @default.
- NCIT_C71726 inSubset NCIT_C116977 @default.
- NCIT_C71726 inSubset NCIT_C116978 @default.
- NCIT_C71726 inSubset NCIT_C128784 @default.
- NCIT_C71726 inSubset NCIT_C157711 @default.
- NCIT_C71726 inSubset NCIT_C157712 @default.
- NCIT_C71726 inSubset NCIT_C176424 @default.
- NCIT_C71726 inSubset NCIT_C177537 @default.
- NCIT_C71726 inSubset NCIT_C63923 @default.
- NCIT_C71726 type Class @default.
- NCIT_C71726 isDefinedBy ncit.owl @default.
- NCIT_C71726 label "Quarfloxin" @default.
- NCIT_C71726 subClassOf NCIT_C1908 @default.
- NCIT_C71726 subClassOf NCIT_C1909 @default.
- NCIT_C71726 subClassOf NCIT_C254 @default.
- NCIT_C71726 subClassOf NCIT_C25995 @default.
- NCIT_C71726 subClassOf NCIT_C471 @default.
- NCIT_C71726 subClassOf NCIT_C52588 @default.
- NCIT_C71726 subClassOf NCIT_C71726 @default.