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- NCIT_C71734 IAO_0000115 "A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-). In addition, nifurtimox-derived nitro anion free radicals may alkylate macromolecules such as nucleic acids and proteins, resulting in the disruption of their structure and function." @default.
- NCIT_C71734 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71734 NCIT_NHC0 "C71734" @default.
- NCIT_C71734 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71734 NCIT_P108 "Nifurtimox" @default.
- NCIT_C71734 NCIT_P207 "C0028073" @default.
- NCIT_C71734 NCIT_P210 "23256-30-6" @default.
- NCIT_C71734 NCIT_P319 "M84I3K7C2O" @default.
- NCIT_C71734 NCIT_P322 "FDA" @default.
- NCIT_C71734 NCIT_P322 "GDC" @default.
- NCIT_C71734 NCIT_P329 "558911" @default.
- NCIT_C71734 NCIT_P330 "558911" @default.
- NCIT_C71734 NCIT_P350 "C10H13N3O5S" @default.
- NCIT_C71734 NCIT_P366 "Nifurtimox" @default.
- NCIT_C71734 NCIT_P375 "Nifurtimox" @default.
- NCIT_C71734 NCIT_P399 "558911" @default.
- NCIT_C71734 normalizedInformationContent "100" @default.
- NCIT_C71734 referenceCount "1" @default.
- NCIT_C71734 hasExactSynonym "4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine-1,1-dioxide" @default.
- NCIT_C71734 hasExactSynonym "BAY 2502" @default.
- NCIT_C71734 hasExactSynonym "BAYER 2502" @default.
- NCIT_C71734 hasExactSynonym "Lampit" @default.
- NCIT_C71734 hasExactSynonym "NIFURTIMOX" @default.
- NCIT_C71734 hasExactSynonym "Nifurtimox" @default.
- NCIT_C71734 inSubset NCIT_C128784 @default.
- NCIT_C71734 inSubset NCIT_C157711 @default.
- NCIT_C71734 inSubset NCIT_C157712 @default.
- NCIT_C71734 inSubset NCIT_C176424 @default.
- NCIT_C71734 inSubset NCIT_C177537 @default.
- NCIT_C71734 inSubset NCIT_C63923 @default.
- NCIT_C71734 type Class @default.
- NCIT_C71734 isDefinedBy ncit.owl @default.
- NCIT_C71734 label "Nifurtimox" @default.
- NCIT_C71734 subClassOf NCIT_C1908 @default.
- NCIT_C71734 subClassOf NCIT_C1909 @default.
- NCIT_C71734 subClassOf NCIT_C254 @default.
- NCIT_C71734 subClassOf NCIT_C276 @default.
- NCIT_C71734 subClassOf NCIT_C277 @default.
- NCIT_C71734 subClassOf NCIT_C71734 @default.