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- NCIT_C71744 IAO_0000115 "An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance." @default.
- NCIT_C71744 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71744 NCIT_A7 NCIT_C17063 @default.
- NCIT_C71744 NCIT_NHC0 "C71744" @default.
- NCIT_C71744 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71744 NCIT_P107 "Enzalutamide" @default.
- NCIT_C71744 NCIT_P108 "Enzalutamide" @default.
- NCIT_C71744 NCIT_P207 "C2348174" @default.
- NCIT_C71744 NCIT_P210 "915087-33-1" @default.
- NCIT_C71744 NCIT_P302 "castration-resistant prostate cancer (CRPC)" @default.
- NCIT_C71744 NCIT_P319 "93T0T9GKNU" @default.
- NCIT_C71744 NCIT_P322 "CTRP" @default.
- NCIT_C71744 NCIT_P322 "FDA" @default.
- NCIT_C71744 NCIT_P322 "GDC" @default.
- NCIT_C71744 NCIT_P322 "OORO" @default.
- NCIT_C71744 NCIT_P329 "560774" @default.
- NCIT_C71744 NCIT_P330 "560774" @default.
- NCIT_C71744 NCIT_P350 "C21H16F4N4O2S" @default.
- NCIT_C71744 NCIT_P366 "Selective_Androgen_Receptor_Modulator_MDV3100" @default.
- NCIT_C71744 NCIT_P375 "Enzalutamide" @default.
- NCIT_C71744 NCIT_P399 "560774" @default.
- NCIT_C71744 normalizedInformationContent "88.143637090998837" @default.
- NCIT_C71744 referenceCount "6" @default.
- NCIT_C71744 hasExactSynonym "ASP9785" @default.
- NCIT_C71744 hasExactSynonym "Benzamide, 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-methyl-" @default.
- NCIT_C71744 hasExactSynonym "ENZALUTAMIDE" @default.
- NCIT_C71744 hasExactSynonym "Enzalutamide" @default.
- NCIT_C71744 hasExactSynonym "MDV3100" @default.
- NCIT_C71744 hasExactSynonym "Xtandi" @default.
- NCIT_C71744 hasExactSynonym "enzalutamide" @default.
- NCIT_C71744 inSubset NCIT_C116977 @default.
- NCIT_C71744 inSubset NCIT_C116978 @default.
- NCIT_C71744 inSubset NCIT_C128784 @default.
- NCIT_C71744 inSubset NCIT_C157711 @default.
- NCIT_C71744 inSubset NCIT_C157712 @default.
- NCIT_C71744 inSubset NCIT_C173381 @default.
- NCIT_C71744 inSubset NCIT_C173383 @default.
- NCIT_C71744 inSubset NCIT_C176424 @default.
- NCIT_C71744 inSubset NCIT_C177537 @default.
- NCIT_C71744 inSubset NCIT_C192234 @default.
- NCIT_C71744 inSubset NCIT_C63923 @default.
- NCIT_C71744 type Class @default.
- NCIT_C71744 isDefinedBy ncit.owl @default.
- NCIT_C71744 label "Enzalutamide" @default.
- NCIT_C71744 subClassOf NCIT_C146993 @default.
- NCIT_C71744 subClassOf NCIT_C147908 @default.
- NCIT_C71744 subClassOf NCIT_C163758 @default.
- NCIT_C71744 subClassOf NCIT_C1908 @default.
- NCIT_C71744 subClassOf NCIT_C1909 @default.
- NCIT_C71744 subClassOf NCIT_C242 @default.
- NCIT_C71744 subClassOf NCIT_C274 @default.
- NCIT_C71744 subClassOf NCIT_C547 @default.
- NCIT_C71744 subClassOf NCIT_C71744 @default.