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- NCIT_C71748 IAO_0000115 "Human autologous peripheral blood lymphocytes (PBLs) transduced with a glycoprotein 100 (gp100) epitope-determined T cell receptor (TCR) gene, with potential antineoplastic activity. PBLs are isolated from a melanoma patient and pulsed with a viral vector encoding the TCR specific for amino acid residues 154-162 of gp100 (KTWGQYWQV). After expansion ex vivo, the transduced autologous PBLs, expressing this specific TCR, are reintroduced into the patient and bind to melanoma cells expressing the gp100 protein, which may result in specific cytotoxic T-lymphocyte (CTL) killing of gp100-expressing melanoma cells. gp100 is a melanocyte lineage-specific antigen overexpressed in melanomas." @default.
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- NCIT_C71748 NCIT_P107 "Autologous Anti-gp100:154-162 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes" @default.
- NCIT_C71748 NCIT_P108 "Autologous Anti-gp100:154-162 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes" @default.
- NCIT_C71748 NCIT_P208 "CL376139" @default.
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- NCIT_C71748 NCIT_P366 "Autologous_Anti-gp100_154-162_TCR_Gene-engineered_PBL" @default.
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- NCIT_C71748 hasExactSynonym "Anti-p53 TCR-Transduced PBL" @default.
- NCIT_C71748 hasExactSynonym "Autologous Anti-gp100:154-162 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes" @default.
- NCIT_C71748 hasExactSynonym "Autologous Anti-gp100:154-162 TCR Gene-Engineered PBL" @default.
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- NCIT_C71748 label "Autologous Anti-gp100:154-162 T-Cell Receptor Gene-Engineered Peripheral Blood Lymphocytes" @default.
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