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- NCIT_C71750 IAO_0000115 "An orally bioavailable synthetic carbothioamide with potential antineoplastic activity. Multitargeted receptor tyrosine kinase inhibitor MP470 binds to mutant forms of the stem cell factor receptor (c-Kit; SCFR), inhibiting clinically relevant mutants of this receptor tyrosine kinase that may be associated with resistance to therapy. In addition, MP470 inhibits activities of other receptor tyrosine kinases, such as c-Met, Ret oncoprotein, and mutant forms of Flt3 and PDGFR alpha, which are frequently dysregulated in variety of tumors. This agent also suppresses the induction of DNA repair protein Rad51, thereby potentiating the activities of DNA damage-inducing agents. Mutant forms of c-Kit are often associated with tumor chemoresistance." @default.
- NCIT_C71750 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71750 NCIT_A5 NCIT_C95776 @default.
- NCIT_C71750 NCIT_A7 NCIT_C17328 @default.
- NCIT_C71750 NCIT_NHC0 "C71750" @default.
- NCIT_C71750 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71750 NCIT_P107 "Amuvatinib" @default.
- NCIT_C71750 NCIT_P108 "Amuvatinib" @default.
- NCIT_C71750 NCIT_P207 "C1958331" @default.
- NCIT_C71750 NCIT_P210 "850879-09-3" @default.
- NCIT_C71750 NCIT_P319 "SO9S6QZB4R" @default.
- NCIT_C71750 NCIT_P322 "CTRP" @default.
- NCIT_C71750 NCIT_P322 "FDA" @default.
- NCIT_C71750 NCIT_P322 "GDC" @default.
- NCIT_C71750 NCIT_P325 "A substance being studied in the treatment of several types of cancer. It blocks the action of certain enzymes involved in cell growth and the repair of DNA damaged by some anticancer drugs. It is a type of tyrosine kinase inhibitor and a type of recombinase inhibitor." @default.
- NCIT_C71750 NCIT_P329 "559320" @default.
- NCIT_C71750 NCIT_P330 "559320" @default.
- NCIT_C71750 NCIT_P350 "C23H21N5O3S" @default.
- NCIT_C71750 NCIT_P366 "Receptor_Tyrosine_Kinase_Inhibitor_MP470" @default.
- NCIT_C71750 NCIT_P375 "Amuvatinib" @default.
- NCIT_C71750 NCIT_P399 "559320" @default.
- NCIT_C71750 normalizedInformationContent "100" @default.
- NCIT_C71750 referenceCount "1" @default.
- NCIT_C71750 hasExactSynonym "AMUVATINIB" @default.
- NCIT_C71750 hasExactSynonym "Amuvatinib" @default.
- NCIT_C71750 hasExactSynonym "HPK56" @default.
- NCIT_C71750 hasExactSynonym "MP470" @default.
- NCIT_C71750 hasExactSynonym "Receptor Tyrosine Kinase Inhibitor MP470" @default.
- NCIT_C71750 inSubset NCIT_C116977 @default.
- NCIT_C71750 inSubset NCIT_C116978 @default.
- NCIT_C71750 inSubset NCIT_C128784 @default.
- NCIT_C71750 inSubset NCIT_C157711 @default.
- NCIT_C71750 inSubset NCIT_C157712 @default.
- NCIT_C71750 inSubset NCIT_C176424 @default.
- NCIT_C71750 inSubset NCIT_C177537 @default.
- NCIT_C71750 inSubset NCIT_C63923 @default.
- NCIT_C71750 type Class @default.
- NCIT_C71750 isDefinedBy ncit.owl @default.
- NCIT_C71750 label "Amuvatinib" @default.
- NCIT_C71750 subClassOf NCIT_C129824 @default.
- NCIT_C71750 subClassOf NCIT_C129825 @default.
- NCIT_C71750 subClassOf NCIT_C1404 @default.
- NCIT_C71750 subClassOf NCIT_C159198 @default.
- NCIT_C71750 subClassOf NCIT_C163758 @default.
- NCIT_C71750 subClassOf NCIT_C163999 @default.
- NCIT_C71750 subClassOf NCIT_C1908 @default.
- NCIT_C71750 subClassOf NCIT_C1909 @default.
- NCIT_C71750 subClassOf NCIT_C1967 @default.
- NCIT_C71750 subClassOf NCIT_C2189 @default.
- NCIT_C71750 subClassOf NCIT_C274 @default.
- NCIT_C71750 subClassOf NCIT_C471 @default.
- NCIT_C71750 subClassOf NCIT_C71750 @default.