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- NCIT_C71759 IAO_0000115 "An orally bioavailable receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Linifanib inhibits members of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor families; it exhibits much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. This agent does not have a general antiproliferative effect due to its high dose requirement. However, linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as FMS-related tyrosine kinase receptor-3 (FLT3)." @default.
- NCIT_C71759 NCIT_A32 NCIT_C1909 @default.
- NCIT_C71759 NCIT_A7 NCIT_C17293 @default.
- NCIT_C71759 NCIT_A7 NCIT_C17322 @default.
- NCIT_C71759 NCIT_NHC0 "C71759" @default.
- NCIT_C71759 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C71759 NCIT_P107 "Linifanib" @default.
- NCIT_C71759 NCIT_P108 "Linifanib" @default.
- NCIT_C71759 NCIT_P207 "C4048786" @default.
- NCIT_C71759 NCIT_P210 "796967-16-3" @default.
- NCIT_C71759 NCIT_P319 "CO93X137CW" @default.
- NCIT_C71759 NCIT_P322 "CTRP" @default.
- NCIT_C71759 NCIT_P322 "FDA" @default.
- NCIT_C71759 NCIT_P322 "GDC" @default.
- NCIT_C71759 NCIT_P325 "A substance being studied in the treatment of several types of cancer. ABT-869 blocks the action of several growth factors. It may also block the growth of new blood vessels that tumors need to grow and may cause cancer cells to die. It is a type of receptor tyrosine kinase inhibitor and a type of angiogensis inhibitor." @default.
- NCIT_C71759 NCIT_P329 "558913" @default.
- NCIT_C71759 NCIT_P330 "558913" @default.
- NCIT_C71759 NCIT_P350 "C21H18FN5O" @default.
- NCIT_C71759 NCIT_P366 "Receptor_Tyrosine_Kinase_Inhibitor_ABT-869" @default.
- NCIT_C71759 NCIT_P375 "Linifanib" @default.
- NCIT_C71759 NCIT_P399 "558913" @default.
- NCIT_C71759 normalizedInformationContent "100" @default.
- NCIT_C71759 referenceCount "1" @default.
- NCIT_C71759 hasExactSynonym "ABT-869" @default.
- NCIT_C71759 hasExactSynonym "LINIFANIB" @default.
- NCIT_C71759 hasExactSynonym "Linifanib" @default.
- NCIT_C71759 hasExactSynonym "multitargeted receptor tyrosine kinase inhibitor ABT-869" @default.
- NCIT_C71759 inSubset NCIT_C116977 @default.
- NCIT_C71759 inSubset NCIT_C116978 @default.
- NCIT_C71759 inSubset NCIT_C128784 @default.
- NCIT_C71759 inSubset NCIT_C157711 @default.
- NCIT_C71759 inSubset NCIT_C157712 @default.
- NCIT_C71759 inSubset NCIT_C176424 @default.
- NCIT_C71759 inSubset NCIT_C177537 @default.
- NCIT_C71759 inSubset NCIT_C63923 @default.
- NCIT_C71759 type Class @default.
- NCIT_C71759 isDefinedBy ncit.owl @default.
- NCIT_C71759 label "Linifanib" @default.
- NCIT_C71759 subClassOf NCIT_C1404 @default.
- NCIT_C71759 subClassOf NCIT_C159199 @default.
- NCIT_C71759 subClassOf NCIT_C163758 @default.
- NCIT_C71759 subClassOf NCIT_C163953 @default.
- NCIT_C71759 subClassOf NCIT_C164037 @default.
- NCIT_C71759 subClassOf NCIT_C1742 @default.
- NCIT_C71759 subClassOf NCIT_C1908 @default.
- NCIT_C71759 subClassOf NCIT_C1909 @default.
- NCIT_C71759 subClassOf NCIT_C1967 @default.
- NCIT_C71759 subClassOf NCIT_C274 @default.
- NCIT_C71759 subClassOf NCIT_C471 @default.
- NCIT_C71759 subClassOf NCIT_C71759 @default.
- NCIT_C71759 subClassOf NCIT_C93259 @default.