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- NCIT_C72672 IAO_0000115 "A murine IgG2a lambda monoclonal antibody, both unradiolabeled and radiolabeled with iodine I 131, directed against the human B cell-specific surface antigen CD20. Tositumomab binds to CD20, resulting in complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), and apoptosis in B cells expressing CD20; in addition to the antibody-mediated cytotoxicity, iodine I 131 tositumomab delivers cytotoxic ionizing radiation specifically to CD20-expressing B cells. In a two-step therapeutic regimen, a predose of unradiolabeled tositumomab is administered first followed by the administration of a dosimetric dose of iodine I 131 tositumomab; 7-14 days later, a therapeutic dose of iodine I 131 tositumomab is administered. The predose of unradiolabeled tositumomab binds to nontumor B cells, increasing the terminal half-life of radiolabeled antibody while protecting nontumor B cells from radiolabeled antibody-mediated radiocytotoxicity." @default.
- NCIT_C72672 NCIT_NHC0 "C72672" @default.
- NCIT_C72672 NCIT_P106 "Therapeutic or Preventive Procedure" @default.
- NCIT_C72672 NCIT_P107 "Tositumomab and Iodine I 131 Tositumomab" @default.
- NCIT_C72672 NCIT_P108 "Tositumomab and Iodine I 131 Tositumomab" @default.
- NCIT_C72672 NCIT_P208 "CL378645" @default.
- NCIT_C72672 NCIT_P310 "Obsolete_Concept" @default.
- NCIT_C72672 NCIT_P322 "CTRP" @default.
- NCIT_C72672 NCIT_P325 "A combination of monoclonal antibodies used to treat certain types of non-Hodgkin lymphoma. The monoclonal antibody tositumomab is given with iodine I 131 tositumomab (a form of tositumomab that has been chemically changed by adding radioactive iodine). Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells." @default.
- NCIT_C72672 NCIT_P329 "588881" @default.
- NCIT_C72672 NCIT_P330 "588881" @default.
- NCIT_C72672 NCIT_P366 "Tositumomab_I-131_Tositumomab" @default.
- NCIT_C72672 NCIT_P399 "588881" @default.
- NCIT_C72672 NCIT_R123 NCIT_C129819 @default.
- NCIT_C72672 NCIT_R123 NCIT_C129821 @default.
- NCIT_C72672 NCIT_R123 NCIT_C129822 @default.
- NCIT_C72672 NCIT_R123 NCIT_C141215 @default.
- NCIT_C72672 NCIT_R123 NCIT_C1446 @default.
- NCIT_C72672 NCIT_R123 NCIT_C1511 @default.
- NCIT_C72672 NCIT_R123 NCIT_C1512 @default.
- NCIT_C72672 NCIT_R123 NCIT_C163758 @default.
- NCIT_C72672 NCIT_R123 NCIT_C164034 @default.
- NCIT_C72672 NCIT_R123 NCIT_C1908 @default.
- NCIT_C72672 NCIT_R123 NCIT_C1909 @default.
- NCIT_C72672 NCIT_R123 NCIT_C20401 @default.
- NCIT_C72672 NCIT_R123 NCIT_C2124 @default.
- NCIT_C72672 NCIT_R123 NCIT_C2444 @default.
- NCIT_C72672 NCIT_R123 NCIT_C2543 @default.
- NCIT_C72672 NCIT_R123 NCIT_C274 @default.
- NCIT_C72672 NCIT_R123 NCIT_C307 @default.
- NCIT_C72672 NCIT_R123 NCIT_C308 @default.
- NCIT_C72672 normalizedInformationContent "100" @default.
- NCIT_C72672 referenceCount "1" @default.
- NCIT_C72672 hasExactSynonym "Bexxar Dosimetric" @default.
- NCIT_C72672 hasExactSynonym "Bexxar Therapeutic Regimen" @default.
- NCIT_C72672 hasExactSynonym "Bexxar Therapeutic" @default.
- NCIT_C72672 hasExactSynonym "Bexxar regimen" @default.
- NCIT_C72672 hasExactSynonym "Tositumomab and Iodine I 131 Tositumomab" @default.
- NCIT_C72672 hasExactSynonym "tositumomab and iodine I 131 tositumomab" @default.
- NCIT_C72672 hasExactSynonym "tositumomab" @default.
- NCIT_C72672 inSubset NCIT_C116977 @default.
- NCIT_C72672 inSubset NCIT_C116978 @default.
- NCIT_C72672 inSubset NCIT_C160950 @default.
- NCIT_C72672 inSubset NCIT_C160952 @default.
- NCIT_C72672 inSubset NCIT_C176424 @default.
- NCIT_C72672 type Class @default.
- NCIT_C72672 isDefinedBy ncit.owl @default.
- NCIT_C72672 label "Tositumomab and Iodine I 131 Tositumomab" @default.
- NCIT_C72672 subClassOf B188324db4a8ce5bd5f3540bbf8994d08 @default.
- NCIT_C72672 subClassOf B74105ec92162376304365dea0b39e3ad @default.
- NCIT_C72672 subClassOf Be74c8cdae38652b9a2eae9b9fc5c5048 @default.
- NCIT_C72672 subClassOf Bf8f5fdff91761060a7e3352b8e3cd3eb @default.
- NCIT_C72672 subClassOf NCIT_C12218 @default.
- NCIT_C72672 subClassOf NCIT_C61007 @default.
- NCIT_C72672 subClassOf NCIT_C62633 @default.
- NCIT_C72672 subClassOf NCIT_C72672 @default.