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- NCIT_C72694 IAO_0000115 "An orally bioavailable, selective antagonist of the endothelin type-A (ETA) receptor that may be used for the treatment of pulmonary arterial hypertension (PAH). Upon administration, ambrisentan targets and binds to ETA receptor, which prevents the binding of endothelin-1 (ET-1) to the ETA receptor and ET-1/ETA-mediated vasoconstriction and cell proliferation. This may lead to vasodilation. ET-1 concentrations are increased in plasma as well as lung tissue in PAH, and ET-1 may play a key role in the pathogenesis of PAH." @default.
- NCIT_C72694 NCIT_NHC0 "C72694" @default.
- NCIT_C72694 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C72694 NCIT_P108 "Ambrisentan" @default.
- NCIT_C72694 NCIT_P207 "C1176329" @default.
- NCIT_C72694 NCIT_P210 "177036-94-1" @default.
- NCIT_C72694 NCIT_P319 "HW6NV07QEC" @default.
- NCIT_C72694 NCIT_P322 "FDA" @default.
- NCIT_C72694 NCIT_P350 "C22H22N2O4" @default.
- NCIT_C72694 NCIT_P366 "Ambrisentan" @default.
- NCIT_C72694 normalizedInformationContent "100" @default.
- NCIT_C72694 referenceCount "1" @default.
- NCIT_C72694 hasExactSynonym "(+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic Acid" @default.
- NCIT_C72694 hasExactSynonym "AMBRISENTAN" @default.
- NCIT_C72694 hasExactSynonym "Ambrisentan" @default.
- NCIT_C72694 hasExactSynonym "BSF-208075" @default.
- NCIT_C72694 hasExactSynonym "LU-208075" @default.
- NCIT_C72694 hasExactSynonym "Letairis" @default.
- NCIT_C72694 hasExactSynonym "Pulmonext" @default.
- NCIT_C72694 hasExactSynonym "Volibris" @default.
- NCIT_C72694 inSubset NCIT_C173381 @default.
- NCIT_C72694 inSubset NCIT_C173383 @default.
- NCIT_C72694 inSubset NCIT_C63923 @default.
- NCIT_C72694 type Class @default.
- NCIT_C72694 isDefinedBy ncit.owl @default.
- NCIT_C72694 label "Ambrisentan" @default.
- NCIT_C72694 subClassOf NCIT_C1908 @default.
- NCIT_C72694 subClassOf NCIT_C1909 @default.
- NCIT_C72694 subClassOf NCIT_C270 @default.
- NCIT_C72694 subClassOf NCIT_C28313 @default.
- NCIT_C72694 subClassOf NCIT_C28334 @default.
- NCIT_C72694 subClassOf NCIT_C72694 @default.
- NCIT_C72694 subClassOf NCIT_C78274 @default.