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- NCIT_C72907 IAO_0000115 "The active metabolite of benazepril, a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Once the prodrug benazepril is metabolized to benazeprilat in the liver, benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow." @default.
- NCIT_C72907 NCIT_NHC0 "C72907" @default.
- NCIT_C72907 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C72907 NCIT_P108 "Benazeprilat" @default.
- NCIT_C72907 NCIT_P207 "C0105523" @default.
- NCIT_C72907 NCIT_P210 "86541-78-8" @default.
- NCIT_C72907 NCIT_P319 "JRM708L703" @default.
- NCIT_C72907 NCIT_P322 "FDA" @default.
- NCIT_C72907 NCIT_P350 "C22H24N2O5" @default.
- NCIT_C72907 NCIT_P366 "Benazeprilat" @default.
- NCIT_C72907 normalizedInformationContent "100" @default.
- NCIT_C72907 referenceCount "1" @default.
- NCIT_C72907 hasExactSynonym "BENAZEPRILAT" @default.
- NCIT_C72907 hasExactSynonym "Benazeprilat" @default.
- NCIT_C72907 inSubset NCIT_C63923 @default.
- NCIT_C72907 type Class @default.
- NCIT_C72907 isDefinedBy ncit.owl @default.
- NCIT_C72907 label "Benazeprilat" @default.
- NCIT_C72907 subClassOf NCIT_C1908 @default.
- NCIT_C72907 subClassOf NCIT_C1909 @default.
- NCIT_C72907 subClassOf NCIT_C247 @default.
- NCIT_C72907 subClassOf NCIT_C270 @default.
- NCIT_C72907 subClassOf NCIT_C471 @default.
- NCIT_C72907 subClassOf NCIT_C72907 @default.
- NCIT_C72907 subClassOf NCIT_C78274 @default.
- NCIT_C72907 subClassOf NCIT_C783 @default.