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- NCIT_C72908 IAO_0000115 "An angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow." @default.
- NCIT_C72908 NCIT_A5 NCIT_C99550 @default.
- NCIT_C72908 NCIT_NHC0 "C72908" @default.
- NCIT_C72908 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C72908 NCIT_P108 "Imidapril" @default.
- NCIT_C72908 NCIT_P207 "C0165703" @default.
- NCIT_C72908 NCIT_P210 "89371-37-9" @default.
- NCIT_C72908 NCIT_P319 "BW7H1TJS22" @default.
- NCIT_C72908 NCIT_P322 "FDA" @default.
- NCIT_C72908 NCIT_P350 "C20H27N3O6" @default.
- NCIT_C72908 NCIT_P366 "Imidapril" @default.
- NCIT_C72908 normalizedInformationContent "100" @default.
- NCIT_C72908 referenceCount "1" @default.
- NCIT_C72908 hasExactSynonym "(S)-3-(N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-1-methyl-2-oxoimidazoline-4-carboxylic acid" @default.
- NCIT_C72908 hasExactSynonym "IMIDAPRIL" @default.
- NCIT_C72908 hasExactSynonym "Imidapril" @default.
- NCIT_C72908 inSubset NCIT_C63923 @default.
- NCIT_C72908 type Class @default.
- NCIT_C72908 isDefinedBy ncit.owl @default.
- NCIT_C72908 label "Imidapril" @default.
- NCIT_C72908 subClassOf NCIT_C1908 @default.
- NCIT_C72908 subClassOf NCIT_C1909 @default.
- NCIT_C72908 subClassOf NCIT_C247 @default.
- NCIT_C72908 subClassOf NCIT_C270 @default.
- NCIT_C72908 subClassOf NCIT_C471 @default.
- NCIT_C72908 subClassOf NCIT_C72908 @default.
- NCIT_C72908 subClassOf NCIT_C78274 @default.
- NCIT_C72908 subClassOf NCIT_C783 @default.