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- NCIT_C732 IAO_0000115 "A purine nucleotide analogue antibiotic isolated from the bacterium Streptomyces antibioticus. Also known as 2'-deoxycoformycin, pentostatin binds to and inhibits adenine deaminase (ADA), an enzyme essential to purine metabolism; ADA activity is greatest in cells of the lymphoid system with T-cells having higher activity than B-cells and T-cell malignancies higher ADA activity than B-cell malignancies. Pentostatin inhibition of ADA appears to result in elevated intracellular levels of dATP which may block DNA synthesis through the inhibition of ribonucleotide reductase. This agent may also inhibit RNA synthesis and may selectively deplete CD26+ lymphocytes. (NCI04)" @default.
- NCIT_C732 NCIT_A32 NCIT_C1909 @default.
- NCIT_C732 NCIT_A7 NCIT_C16261 @default.
- NCIT_C732 NCIT_NHC0 "C732" @default.
- NCIT_C732 NCIT_P106 "Antibiotic" @default.
- NCIT_C732 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C732 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C732 NCIT_P107 "Pentostatin" @default.
- NCIT_C732 NCIT_P108 "Pentostatin" @default.
- NCIT_C732 NCIT_P175 "218321" @default.
- NCIT_C732 NCIT_P175 "247520" @default.
- NCIT_C732 NCIT_P207 "C0030896" @default.
- NCIT_C732 NCIT_P210 "53910-25-1" @default.
- NCIT_C732 NCIT_P210 "63677-95-2" @default.
- NCIT_C732 NCIT_P302 "Chronic lymphocytic leukemia; Cutaneous t-cell lymphoma; Hairy cell leukemia" @default.
- NCIT_C732 NCIT_P319 "395575MZO7" @default.
- NCIT_C732 NCIT_P322 "CTRP" @default.
- NCIT_C732 NCIT_P322 "FDA" @default.
- NCIT_C732 NCIT_P322 "GDC" @default.
- NCIT_C732 NCIT_P325 "The active ingredient in a drug that is used to treat hairy cell leukemia and is being studied in the treatment of other types of cancer. Pentostatin blocks a protein needed for cell growth and may kill cancer cells. It is made by a bacterium. It is a type of adenosine deaminase inhibitor." @default.
- NCIT_C732 NCIT_P329 "39210" @default.
- NCIT_C732 NCIT_P330 "39210" @default.
- NCIT_C732 NCIT_P350 "C11H16N4O4" @default.
- NCIT_C732 NCIT_P366 "Pentostatin" @default.
- NCIT_C732 NCIT_P375 "Pentostatin" @default.
- NCIT_C732 NCIT_P399 "39210" @default.
- NCIT_C732 NCIT_R124 NCIT_C17710 @default.
- NCIT_C732 NCIT_R124 NCIT_C17828 @default.
- NCIT_C732 NCIT_R124 NCIT_C28498 @default.
- NCIT_C732 NCIT_R124 NCIT_C40576 @default.
- NCIT_C732 NCIT_R124 NCIT_C40577 @default.
- NCIT_C732 NCIT_R125 NCIT_C17710 @default.
- NCIT_C732 NCIT_R125 NCIT_C17828 @default.
- NCIT_C732 NCIT_R125 NCIT_C19403 @default.
- NCIT_C732 NCIT_R125 NCIT_C19536 @default.
- NCIT_C732 NCIT_R125 NCIT_C21198 @default.
- NCIT_C732 NCIT_R125 NCIT_C28498 @default.
- NCIT_C732 NCIT_R125 NCIT_C41621 @default.
- NCIT_C732 NCIT_R146 NCIT_C16261 @default.
- NCIT_C732 NCIT_R146 NCIT_C16554 @default.
- NCIT_C732 NCIT_R146 NCIT_C16701 @default.
- NCIT_C732 NCIT_R146 NCIT_C17021 @default.
- NCIT_C732 NCIT_R146 NCIT_C20027 @default.
- NCIT_C732 NCIT_R146 NCIT_C26548 @default.
- NCIT_C732 NCIT_R72 NCIT_C12219 @default.
- NCIT_C732 NCIT_R72 NCIT_C12508 @default.
- NCIT_C732 NCIT_R72 NCIT_C12535 @default.
- NCIT_C732 NCIT_R72 NCIT_C21599 @default.
- NCIT_C732 NCIT_R72 NCIT_C32725 @default.
- NCIT_C732 normalizedInformationContent "81.653330900245635" @default.
- NCIT_C732 referenceCount "16" @default.
- NCIT_C732 hasExactSynonym "(R)-3-(2-Deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7, 8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol" @default.
- NCIT_C732 hasExactSynonym "(R)-3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol" @default.
- NCIT_C732 hasExactSynonym "2'-Deoxycoformycin" @default.
- NCIT_C732 hasExactSynonym "CI-825" @default.
- NCIT_C732 hasExactSynonym "Co-Vidarabine" @default.
- NCIT_C732 hasExactSynonym "Co-vidarabine" @default.
- NCIT_C732 hasExactSynonym "Covidarabine" @default.
- NCIT_C732 hasExactSynonym "DCF" @default.
- NCIT_C732 hasExactSynonym "Deoxycoformycin" @default.
- NCIT_C732 hasExactSynonym "Nipent" @default.
- NCIT_C732 hasExactSynonym "PD-81565" @default.
- NCIT_C732 hasExactSynonym "PENTOSTATIN" @default.
- NCIT_C732 hasExactSynonym "Pentostatin" @default.
- NCIT_C732 hasExactSynonym "Pentostatine" @default.
- NCIT_C732 hasExactSynonym "pentostatin" @default.
- NCIT_C732 inSubset NCIT_C116977 @default.
- NCIT_C732 inSubset NCIT_C116978 @default.
- NCIT_C732 inSubset NCIT_C128784 @default.
- NCIT_C732 inSubset NCIT_C157711 @default.
- NCIT_C732 inSubset NCIT_C157712 @default.
- NCIT_C732 inSubset NCIT_C176424 @default.
- NCIT_C732 inSubset NCIT_C177537 @default.
- NCIT_C732 inSubset NCIT_C63923 @default.
- NCIT_C732 type Class @default.
- NCIT_C732 isDefinedBy ncit.owl @default.
- NCIT_C732 label "Pentostatin" @default.
- NCIT_C732 subClassOf NCIT_C1908 @default.
- NCIT_C732 subClassOf NCIT_C1909 @default.
- NCIT_C732 subClassOf NCIT_C2157 @default.
- NCIT_C732 subClassOf NCIT_C471 @default.
- NCIT_C732 subClassOf NCIT_C732 @default.
- NCIT_C732 equivalentClass Bd31d78564fbf17e24a3fafcc6eab19f9 @default.
- NCIT_C732 equivalentClass Bfcd7f5190fe6073296522ae02c17d36d @default.