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- NCIT_C73438 IAO_0000115 "A transforming growth factor beta2 (TGF-beta2) antisense gene-modified allogeneic tumor cell vaccine with potential immunostimulatory and antineoplastic activities. Belagenpumatucel-L is prepared by transfecting allogeneic non-small cell lung cancer (NSCLC) cells with a plasmid containing a TGF-beta2 antisense transgene, expanding the cells, and then irradiating and freezing them. Upon administration, this agent may elicit a cytotoxic T lymphocyte (CTL) response against host NSCLC cells, resulting in decreased tumor cell proliferation; vaccine immunogenicity may be potentiated by suppression of tumor TGF-beta2 production by antisense RNA expressed by the vaccine plasmid TGF-beta2 antisense transgene. Elevated levels of TGF-beta2 are frequently linked to immunosuppression in cancer patients and may be inversely correlated with prognosis in patients with NSCLC." @default.
- NCIT_C73438 NCIT_A32 NCIT_C1909 @default.
- NCIT_C73438 NCIT_A7 NCIT_C20458 @default.
- NCIT_C73438 NCIT_NHC0 "C73438" @default.
- NCIT_C73438 NCIT_P106 "Cell" @default.
- NCIT_C73438 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C73438 NCIT_P107 "Belagenpumatucel-L" @default.
- NCIT_C73438 NCIT_P108 "Belagenpumatucel-L" @default.
- NCIT_C73438 NCIT_P207 "C1739687" @default.
- NCIT_C73438 NCIT_P322 "CTRP" @default.
- NCIT_C73438 NCIT_P322 "GDC" @default.
- NCIT_C73438 NCIT_P329 "590662" @default.
- NCIT_C73438 NCIT_P330 "590662" @default.
- NCIT_C73438 NCIT_P366 "Belagenpumatucel-L" @default.
- NCIT_C73438 NCIT_P375 "Belagenpumatucel-L" @default.
- NCIT_C73438 NCIT_P399 "590662" @default.
- NCIT_C73438 normalizedInformationContent "100" @default.
- NCIT_C73438 referenceCount "1" @default.
- NCIT_C73438 hasExactSynonym "Belagenpumatucel-L" @default.
- NCIT_C73438 hasExactSynonym "Lucanix" @default.
- NCIT_C73438 inSubset NCIT_C116977 @default.
- NCIT_C73438 inSubset NCIT_C116978 @default.
- NCIT_C73438 inSubset NCIT_C128784 @default.
- NCIT_C73438 inSubset NCIT_C157711 @default.
- NCIT_C73438 inSubset NCIT_C157712 @default.
- NCIT_C73438 inSubset NCIT_C176424 @default.
- NCIT_C73438 inSubset NCIT_C177537 @default.
- NCIT_C73438 type Class @default.
- NCIT_C73438 isDefinedBy ncit.owl @default.
- NCIT_C73438 label "Belagenpumatucel-L" @default.
- NCIT_C73438 subClassOf NCIT_C129820 @default.
- NCIT_C73438 subClassOf NCIT_C1663 @default.
- NCIT_C73438 subClassOf NCIT_C1908 @default.
- NCIT_C73438 subClassOf NCIT_C1909 @default.
- NCIT_C73438 subClassOf NCIT_C1983 @default.
- NCIT_C73438 subClassOf NCIT_C2341 @default.
- NCIT_C73438 subClassOf NCIT_C274 @default.
- NCIT_C73438 subClassOf NCIT_C307 @default.
- NCIT_C73438 subClassOf NCIT_C308 @default.
- NCIT_C73438 subClassOf NCIT_C73438 @default.
- NCIT_C73438 subClassOf NCIT_C923 @default.