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- NCIT_C73596 IAO_0000115 "The hydrochloride salt form of mebeverine, an orally bioavailable reserpine derivative and anticholinergic agent, with spasmolytic activity. Upon administration, mebeverine targets, binds to and blocks the muscarinic receptors on smooth muscle cells in target tissues, such as the gastrointestinal (GI) tract, uterus, gallbladder and bladder. This prevents smooth muscle contraction and relaxes smooth muscle. Additionally, this may prevent spasms, ease pain and cramps in the GI tract and improve incontinence. In addition, mebeverine stabilizes excitable membranes by decreasing the permeability of ion channels and preventing intracellular calcium accumulation. This agent also blocks noradrenaline reuptake by sympathetic nerve endings and exerts a local anesthetic effect." @default.
- NCIT_C73596 NCIT_A6 NCIT_C83909 @default.
- NCIT_C73596 NCIT_NHC0 "C73596" @default.
- NCIT_C73596 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C73596 NCIT_P108 "Mebeverine Hydrochloride" @default.
- NCIT_C73596 NCIT_P207 "C0771014" @default.
- NCIT_C73596 NCIT_P210 "2753-45-9" @default.
- NCIT_C73596 NCIT_P319 "15VZ5AL4JN" @default.
- NCIT_C73596 NCIT_P322 "FDA" @default.
- NCIT_C73596 NCIT_P329 "792735" @default.
- NCIT_C73596 NCIT_P330 "792735" @default.
- NCIT_C73596 NCIT_P350 "C25H35NO5.HCl" @default.
- NCIT_C73596 NCIT_P366 "Mebeverine_Hydrochloride" @default.
- NCIT_C73596 NCIT_P399 "792735" @default.
- NCIT_C73596 normalizedInformationContent "100" @default.
- NCIT_C73596 referenceCount "1" @default.
- NCIT_C73596 hasExactSynonym "4-(Ethyl(p-methoxy-alpha-methylphenethyl)amino)butyl Veratrate Hydrochloride" @default.
- NCIT_C73596 hasExactSynonym "Benzoic Acid, 3,4-Dimethoxy-, 4-(ethyl(2-(4-methoxyphenyl)-1-methylethyl)amino)butyl Ester, Hydrochloride" @default.
- NCIT_C73596 hasExactSynonym "Colofac" @default.
- NCIT_C73596 hasExactSynonym "MEBEVERINE HYDROCHLORIDE" @default.
- NCIT_C73596 hasExactSynonym "Mebeverine HCl" @default.
- NCIT_C73596 hasExactSynonym "Mebeverine Hydrochloride" @default.
- NCIT_C73596 inSubset NCIT_C176424 @default.
- NCIT_C73596 inSubset NCIT_C63923 @default.
- NCIT_C73596 type Class @default.
- NCIT_C73596 isDefinedBy ncit.owl @default.
- NCIT_C73596 label "Mebeverine Hydrochloride" @default.
- NCIT_C73596 subClassOf NCIT_C1908 @default.
- NCIT_C73596 subClassOf NCIT_C1909 @default.
- NCIT_C73596 subClassOf NCIT_C66880 @default.
- NCIT_C73596 subClassOf NCIT_C73596 @default.
- NCIT_C73596 subClassOf NCIT_C78272 @default.