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- NCIT_C73598 IAO_0000115 "An indole derivative and third-generation selective estrogen receptor modulator (SERM) with potential antineoplastic activity. Upon administration, bazedoxifene specifically binds to estrogen receptors in responsive tissues, including liver, bone, breast, and endometrium. The resulting ligand-receptor complex is translocated to the nucleus where, depending on the tissue type, it either promotes or suppresses the transcription of estrogen-regulated genes. Bazedoxifene acts as an estrogen antagonist in uterine and breast tissue, thereby blocking the proliferative effects of estrogen-binding to ER-positive cells in these tissues. Bazedoxifene functions as an estrogen agonist in lipid metabolism, thereby decreasing total and LDL cholesterol levels. In bone, it decreases bone resorption and bone turnover and increases bone mineral density." @default.
- NCIT_C73598 NCIT_A32 NCIT_C1909 @default.
- NCIT_C73598 NCIT_A5 NCIT_C74212 @default.
- NCIT_C73598 NCIT_A7 NCIT_C38361 @default.
- NCIT_C73598 NCIT_NHC0 "C73598" @default.
- NCIT_C73598 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C73598 NCIT_P107 "Bazedoxifene" @default.
- NCIT_C73598 NCIT_P108 "Bazedoxifene" @default.
- NCIT_C73598 NCIT_P207 "C2346970" @default.
- NCIT_C73598 NCIT_P210 "198481-32-2" @default.
- NCIT_C73598 NCIT_P319 "Q16TT9C5BK" @default.
- NCIT_C73598 NCIT_P322 "CTRP" @default.
- NCIT_C73598 NCIT_P322 "FDA" @default.
- NCIT_C73598 NCIT_P322 "GDC" @default.
- NCIT_C73598 NCIT_P329 "772911" @default.
- NCIT_C73598 NCIT_P330 "772911" @default.
- NCIT_C73598 NCIT_P350 "C30H34N2O3" @default.
- NCIT_C73598 NCIT_P366 "Bazedoxifene" @default.
- NCIT_C73598 NCIT_P375 "Bazedoxifene" @default.
- NCIT_C73598 NCIT_P399 "772911" @default.
- NCIT_C73598 normalizedInformationContent "100" @default.
- NCIT_C73598 referenceCount "1" @default.
- NCIT_C73598 hasExactSynonym "1H-Indol-5-ol, 1-((4-(2-(hexahydro-1H-azepin-1-yl)ethoxy)phenyl)methyl)-2-(4-hydroxyphenyl)-3-methyl-" @default.
- NCIT_C73598 hasExactSynonym "BAZEDOXIFENE" @default.
- NCIT_C73598 hasExactSynonym "Bazedoxifene" @default.
- NCIT_C73598 hasExactSynonym "TSE-424" @default.
- NCIT_C73598 hasExactSynonym "WAY 140424" @default.
- NCIT_C73598 inSubset NCIT_C116977 @default.
- NCIT_C73598 inSubset NCIT_C116978 @default.
- NCIT_C73598 inSubset NCIT_C128784 @default.
- NCIT_C73598 inSubset NCIT_C157711 @default.
- NCIT_C73598 inSubset NCIT_C157712 @default.
- NCIT_C73598 inSubset NCIT_C176424 @default.
- NCIT_C73598 inSubset NCIT_C177537 @default.
- NCIT_C73598 inSubset NCIT_C63923 @default.
- NCIT_C73598 type Class @default.
- NCIT_C73598 isDefinedBy ncit.owl @default.
- NCIT_C73598 label "Bazedoxifene" @default.
- NCIT_C73598 subClassOf NCIT_C129818 @default.
- NCIT_C73598 subClassOf NCIT_C147908 @default.
- NCIT_C73598 subClassOf NCIT_C163758 @default.
- NCIT_C73598 subClassOf NCIT_C1821 @default.
- NCIT_C73598 subClassOf NCIT_C1892 @default.
- NCIT_C73598 subClassOf NCIT_C1908 @default.
- NCIT_C73598 subClassOf NCIT_C1909 @default.
- NCIT_C73598 subClassOf NCIT_C274 @default.
- NCIT_C73598 subClassOf NCIT_C481 @default.
- NCIT_C73598 subClassOf NCIT_C483 @default.
- NCIT_C73598 subClassOf NCIT_C547 @default.
- NCIT_C73598 subClassOf NCIT_C548 @default.
- NCIT_C73598 subClassOf NCIT_C73598 @default.