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- NCIT_C73609 IAO_0000115 "A partial agonist of the nicotinic acetylcholine receptor (nAChR) subtype alpha4beta2. Nicotine stimulation of central alpha4beta2 nAChRs located at presynaptic terminals in the nucleus accumbens causes the release of the neurotransmitter dopamine, which may be associated with the experience of pleasure; nicotine addiction constitutes a physiologic dependence related to this dopaminergic reward system. As an AChR partial agonist, varenicline attenuates the craving and withdrawal symptoms that occur with abstinence from nicotine but is not habit-forming itself." @default.
- NCIT_C73609 NCIT_A5 NCIT_C61998 @default.
- NCIT_C73609 NCIT_NHC0 "C73609" @default.
- NCIT_C73609 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C73609 NCIT_P107 "Varenicline" @default.
- NCIT_C73609 NCIT_P108 "Varenicline" @default.
- NCIT_C73609 NCIT_P207 "C1569608" @default.
- NCIT_C73609 NCIT_P210 "249296-44-4" @default.
- NCIT_C73609 NCIT_P319 "W6HS99O8ZO" @default.
- NCIT_C73609 NCIT_P322 "CTRP" @default.
- NCIT_C73609 NCIT_P322 "FDA" @default.
- NCIT_C73609 NCIT_P325 "A drug used to help people stop smoking by acting the same way nicotine acts in the brain. It is a type of nicotine receptor partial agonist." @default.
- NCIT_C73609 NCIT_P329 "584706" @default.
- NCIT_C73609 NCIT_P330 "584706" @default.
- NCIT_C73609 NCIT_P350 "C13H13N3" @default.
- NCIT_C73609 NCIT_P366 "Varenicline" @default.
- NCIT_C73609 NCIT_P399 "584706" @default.
- NCIT_C73609 normalizedInformationContent "100" @default.
- NCIT_C73609 referenceCount "1" @default.
- NCIT_C73609 hasExactSynonym "7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine (2R,3R)-2,3-dihydroxybutqanedioate" @default.
- NCIT_C73609 hasExactSynonym "CP-526555" @default.
- NCIT_C73609 hasExactSynonym "Champix" @default.
- NCIT_C73609 hasExactSynonym "Chantix" @default.
- NCIT_C73609 hasExactSynonym "VARENICLINE" @default.
- NCIT_C73609 hasExactSynonym "Varenicline" @default.
- NCIT_C73609 inSubset NCIT_C116977 @default.
- NCIT_C73609 inSubset NCIT_C116978 @default.
- NCIT_C73609 inSubset NCIT_C176424 @default.
- NCIT_C73609 inSubset NCIT_C63923 @default.
- NCIT_C73609 type Class @default.
- NCIT_C73609 isDefinedBy ncit.owl @default.
- NCIT_C73609 label "Varenicline" @default.
- NCIT_C73609 subClassOf NCIT_C1908 @default.
- NCIT_C73609 subClassOf NCIT_C1909 @default.
- NCIT_C73609 subClassOf NCIT_C47796 @default.
- NCIT_C73609 subClassOf NCIT_C73579 @default.
- NCIT_C73609 subClassOf NCIT_C73609 @default.
- NCIT_C73609 subClassOf NCIT_C78272 @default.