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- NCIT_C73692 IAO_0000115 "Paired box protein PAX-2 (416aa, ~45 kD) is encoded by the human PAX2 gene. This soluble, nuclear protein plays a role in transcription by RNA polymerase II and cellular proliferation." @default.
- NCIT_C73692 NCIT_NHC0 "C73692" @default.
- NCIT_C73692 NCIT_P100 "167409" @default.
- NCIT_C73692 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C73692 NCIT_P108 "Paired Box Protein Pax-2" @default.
- NCIT_C73692 NCIT_P207 "C1504982" @default.
- NCIT_C73692 NCIT_P366 "Paired_Box_Protein_PAX-2" @default.
- NCIT_C73692 NCIT_P93 "Q02962" @default.
- NCIT_C73692 NCIT_P98 "Presence of PAX2 in tumor cells blocks production of the ERBB2 protein, which fuels tumor growth. An absence or deficiency of PAX2 decreases the effectiveness of tamoxifen. Several new DNA binding sites for Estrogen Receptor were found in the ERBB2 gene, meaning that liganded ER is able to upregulate its own gene. When exposed to tamoxifen, PAX2 binds to ER and ablates this upregulation. The absence of PAX2 may be used to identify patients who will not respond to to tamoxifen, but will respond to alternate therapy, such as aromatase inhibitors. (Nature 2008; 456:663-666)." @default.
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- NCIT_C73692 hasExactSynonym "PAX-2" @default.
- NCIT_C73692 hasExactSynonym "PAX2" @default.
- NCIT_C73692 hasExactSynonym "Paired Box Protein Pax-2" @default.
- NCIT_C73692 type Class @default.
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- NCIT_C73692 label "Paired Box Protein Pax-2" @default.
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