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- NCIT_C73815 IAO_0000115 "The fumarate salt of cevipabulin, a synthetic, water soluble tubulin-binding agent with potential antineoplastic activity. Cevipabulin appears to bind at the vinca-binding site on tubulin, but seems to act more similar to taxane-site binding agents in that it enhances tubulin polymerization and does not induce tubulin depolymerization. The disruption in microtubule dynamics may eventually inhibit cell division and reduce cellular growth., a small, water soluble, synthetic tubulin-binding agent with potential antineoplastic activity. Cevipabulin appears to bind at the vinca-binding site on tubulin, but seems to act more similar to taxane-site binding agents in that it enhances tubulin polymerization and does not induce tubulin depolymerization. The disruption in microtubule dynamics may eventually inhibit cell division and may reduce cellular growth." @default.
- NCIT_C73815 NCIT_A32 NCIT_C1909 @default.
- NCIT_C73815 NCIT_A6 NCIT_C77064 @default.
- NCIT_C73815 NCIT_NHC0 "C73815" @default.
- NCIT_C73815 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C73815 NCIT_P108 "Cevipabulin Fumarate" @default.
- NCIT_C73815 NCIT_P207 "C2347606" @default.
- NCIT_C73815 NCIT_P210 "849550-69-2" @default.
- NCIT_C73815 NCIT_P319 "Q380BYV049" @default.
- NCIT_C73815 NCIT_P322 "FDA" @default.
- NCIT_C73815 NCIT_P322 "GDC" @default.
- NCIT_C73815 NCIT_P350 "C18H18ClF5N6O.C4H4O4.2H2O" @default.
- NCIT_C73815 NCIT_P366 "Cevipabulin_Fumarate" @default.
- NCIT_C73815 NCIT_P375 "Cevipabulin Fumarate" @default.
- NCIT_C73815 NCIT_R124 NCIT_C17828 @default.
- NCIT_C73815 NCIT_R124 NCIT_C20480 @default.
- NCIT_C73815 NCIT_R124 NCIT_C40795 @default.
- NCIT_C73815 NCIT_R124 NCIT_C40798 @default.
- NCIT_C73815 normalizedInformationContent "100" @default.
- NCIT_C73815 referenceCount "1" @default.
- NCIT_C73815 hasExactSynonym "CEVIPABULIN FUMARATE" @default.
- NCIT_C73815 hasExactSynonym "Cevipabulin Fumarate" @default.
- NCIT_C73815 hasExactSynonym "TTI-237" @default.
- NCIT_C73815 hasExactSynonym "[1,2,4]Triazolo[1,5-a]pyrimidin-7-amine, 5-chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-, (2E)-2-butenedioate (1:1), dihydrate" @default.
- NCIT_C73815 inSubset NCIT_C128784 @default.
- NCIT_C73815 inSubset NCIT_C157711 @default.
- NCIT_C73815 inSubset NCIT_C157712 @default.
- NCIT_C73815 inSubset NCIT_C177537 @default.
- NCIT_C73815 inSubset NCIT_C63923 @default.
- NCIT_C73815 type Class @default.
- NCIT_C73815 isDefinedBy ncit.owl @default.
- NCIT_C73815 label "Cevipabulin Fumarate" @default.
- NCIT_C73815 subClassOf NCIT_C186664 @default.
- NCIT_C73815 subClassOf NCIT_C1908 @default.
- NCIT_C73815 subClassOf NCIT_C1909 @default.
- NCIT_C73815 subClassOf NCIT_C25974 @default.
- NCIT_C73815 subClassOf NCIT_C273 @default.
- NCIT_C73815 subClassOf NCIT_C274 @default.
- NCIT_C73815 subClassOf NCIT_C73815 @default.