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- NCIT_C739 IAO_0000115 "A long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain. The activation effects of the phenobarbital-receptor-ionophore complex include increased frequency of chloride channel openings, membrane hyperpolarization and ultimately synaptic inhibition and decreased neuronal excitability. In addition, this agent inhibits glutamate induced depolarization." @default.
- NCIT_C739 NCIT_A5 NCIT_C76956 @default.
- NCIT_C739 NCIT_A5 NCIT_C95059 @default.
- NCIT_C739 NCIT_NHC0 "C739" @default.
- NCIT_C739 NCIT_P106 "Organic Chemical" @default.
- NCIT_C739 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C739 NCIT_P108 "Phenobarbital" @default.
- NCIT_C739 NCIT_P175 "128143" @default.
- NCIT_C739 NCIT_P175 "9848" @default.
- NCIT_C739 NCIT_P207 "C0031412" @default.
- NCIT_C739 NCIT_P210 "50-06-6" @default.
- NCIT_C739 NCIT_P302 "Epilepsy" @default.
- NCIT_C739 NCIT_P319 "YQE403BP4D" @default.
- NCIT_C739 NCIT_P322 "FDA" @default.
- NCIT_C739 NCIT_P325 "A drug that is used to treat seizures and as a sedative. It is being studied in the treatment of diarrhea and for its ability to increase the antitumor effect of other therapies. It belongs to the family of drugs called barbiturates." @default.
- NCIT_C739 NCIT_P329 "42405" @default.
- NCIT_C739 NCIT_P330 "42405" @default.
- NCIT_C739 NCIT_P350 "C12H12N2O3" @default.
- NCIT_C739 NCIT_P366 "Phenobarbital" @default.
- NCIT_C739 NCIT_P368 "CHEBI:8069" @default.
- NCIT_C739 NCIT_P399 "42405" @default.
- NCIT_C739 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C739 referenceCount "2" @default.
- NCIT_C739 hasExactSynonym "5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione" @default.
- NCIT_C739 hasExactSynonym "PHENO" @default.
- NCIT_C739 hasExactSynonym "PHENOBARBITAL" @default.
- NCIT_C739 hasExactSynonym "Phenobarbital" @default.
- NCIT_C739 hasExactSynonym "phenobarbital" @default.
- NCIT_C739 inSubset NCIT_C176424 @default.
- NCIT_C739 inSubset NCIT_C63923 @default.
- NCIT_C739 type Class @default.
- NCIT_C739 isDefinedBy ncit.owl @default.
- NCIT_C739 label "Phenobarbital" @default.
- NCIT_C739 subClassOf NCIT_C1908 @default.
- NCIT_C739 subClassOf NCIT_C1909 @default.
- NCIT_C739 subClassOf NCIT_C264 @default.
- NCIT_C739 subClassOf NCIT_C29756 @default.
- NCIT_C739 subClassOf NCIT_C67084 @default.
- NCIT_C739 subClassOf NCIT_C739 @default.
- NCIT_C739 subClassOf NCIT_C78272 @default.