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- NCIT_C74011 IAO_0000115 "A recombinant humanized monoclonal antibody directed against the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Dalotuzumab binds to membrane-bound IGF1R, preventing binding of the ligand IGF1 and the subsequent triggering of the PI3K/Akt signaling pathway; inhibition of this survival signaling pathway may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. The activation of IGF1R, a tyrosine kinase and a member of the insulin receptor family, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF1R signaling has been highly implicated in tumorigenesis and metastasis." @default.
- NCIT_C74011 NCIT_A32 NCIT_C1909 @default.
- NCIT_C74011 NCIT_NHC0 "C74011" @default.
- NCIT_C74011 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C74011 NCIT_P107 "Dalotuzumab" @default.
- NCIT_C74011 NCIT_P108 "Dalotuzumab" @default.
- NCIT_C74011 NCIT_P207 "C2987605" @default.
- NCIT_C74011 NCIT_P210 "1005389-60-5" @default.
- NCIT_C74011 NCIT_P319 "6YI1L648RH" @default.
- NCIT_C74011 NCIT_P322 "CTRP" @default.
- NCIT_C74011 NCIT_P322 "FDA" @default.
- NCIT_C74011 NCIT_P322 "GDC" @default.
- NCIT_C74011 NCIT_P325 "A substance being studied in the treatment of many types of cancer. MK-0646 binds to a protein called insulin-like growth factor receptor (IGFR) on the surface of cells. This may prevent the cells from growing when IGF is present. It may also kill cancer cells. MK-0646 is a type of monoclonal antibody." @default.
- NCIT_C74011 NCIT_P329 "489297" @default.
- NCIT_C74011 NCIT_P330 "489297" @default.
- NCIT_C74011 NCIT_P366 "Anti-IGF1R_Recombinant_Monoclonal_Antibody_MK-0646" @default.
- NCIT_C74011 NCIT_P375 "Dalotuzumab" @default.
- NCIT_C74011 NCIT_P399 "489297" @default.
- NCIT_C74011 NCIT_R124 NCIT_C17710 @default.
- NCIT_C74011 NCIT_R124 NCIT_C17828 @default.
- NCIT_C74011 NCIT_R124 NCIT_C18219 @default.
- NCIT_C74011 NCIT_R124 NCIT_C19986 @default.
- NCIT_C74011 NCIT_R124 NCIT_C40474 @default.
- NCIT_C74011 normalizedInformationContent "100" @default.
- NCIT_C74011 referenceCount "1" @default.
- NCIT_C74011 hasExactSynonym "Anti-IGF-1R Recombinant Monoclonal Antibody MK-0646" @default.
- NCIT_C74011 hasExactSynonym "DALOTUZUMAB" @default.
- NCIT_C74011 hasExactSynonym "Dalotuzumab" @default.
- NCIT_C74011 hasExactSynonym "MK-0646" @default.
- NCIT_C74011 hasExactSynonym "anti-IGF1R recombinant monoclonal antibody MK-0646" @default.
- NCIT_C74011 inSubset NCIT_C116977 @default.
- NCIT_C74011 inSubset NCIT_C116978 @default.
- NCIT_C74011 inSubset NCIT_C128784 @default.
- NCIT_C74011 inSubset NCIT_C157711 @default.
- NCIT_C74011 inSubset NCIT_C157712 @default.
- NCIT_C74011 inSubset NCIT_C176424 @default.
- NCIT_C74011 inSubset NCIT_C177537 @default.
- NCIT_C74011 inSubset NCIT_C63923 @default.
- NCIT_C74011 type Class @default.
- NCIT_C74011 isDefinedBy ncit.owl @default.
- NCIT_C74011 label "Dalotuzumab" @default.
- NCIT_C74011 subClassOf NCIT_C129821 @default.
- NCIT_C74011 subClassOf NCIT_C129822 @default.
- NCIT_C74011 subClassOf NCIT_C1742 @default.
- NCIT_C74011 subClassOf NCIT_C182012 @default.
- NCIT_C74011 subClassOf NCIT_C1908 @default.
- NCIT_C74011 subClassOf NCIT_C1909 @default.
- NCIT_C74011 subClassOf NCIT_C20401 @default.
- NCIT_C74011 subClassOf NCIT_C274 @default.
- NCIT_C74011 subClassOf NCIT_C307 @default.
- NCIT_C74011 subClassOf NCIT_C308 @default.
- NCIT_C74011 subClassOf NCIT_C74011 @default.