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- NCIT_C74069 IAO_0000115 "An extended-release (ER) formulation composed of irinotecan, which is a semisynthetic derivative of camptothecin and a topoisomerase I-inhibitor prodrug, that is conjugated, via a proprietary biodegradable ester-based linker, to polyethylene glycol (PEG), with antineoplastic activity. Upon administration of etirinotecan pegol (EP), the agent penetrates into the leaky tumor vasculature and accumulates in the tumor. The linker slowly hydrolyzes and releases irinotecan, which leads to sustained exposure of the tumor to irinotecan. In turn, irinotecan is converted to the biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN38) by a carboxylesterase. SN38 inhibits topoisomerase I activity by stabilizing the cleavable complex of topoisomerase I and DNA; this results in DNA breaks that inhibit DNA replication and trigger apoptosis. Pegylation provides improved systemic exposure, increases drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic effects while lowering the toxicity profile." @default.
- NCIT_C74069 NCIT_A32 NCIT_C1909 @default.
- NCIT_C74069 NCIT_A7 NCIT_C16516 @default.
- NCIT_C74069 NCIT_NHC0 "C74069" @default.
- NCIT_C74069 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C74069 NCIT_P107 "Etirinotecan Pegol" @default.
- NCIT_C74069 NCIT_P108 "Etirinotecan Pegol" @default.
- NCIT_C74069 NCIT_P207 "C3659087" @default.
- NCIT_C74069 NCIT_P210 "848779-32-8" @default.
- NCIT_C74069 NCIT_P319 "LJ16641SFT" @default.
- NCIT_C74069 NCIT_P322 "CTRP" @default.
- NCIT_C74069 NCIT_P322 "FDA" @default.
- NCIT_C74069 NCIT_P322 "GDC" @default.
- NCIT_C74069 NCIT_P329 "586949" @default.
- NCIT_C74069 NCIT_P330 "586949" @default.
- NCIT_C74069 NCIT_P366 "Pegylated_Irinotecan_NKTR_102" @default.
- NCIT_C74069 NCIT_P375 "Etirinotecan Pegol" @default.
- NCIT_C74069 NCIT_P399 "586949" @default.
- NCIT_C74069 normalizedInformationContent "100" @default.
- NCIT_C74069 referenceCount "1" @default.
- NCIT_C74069 hasExactSynonym "ETIRINOTECAN PEGOL" @default.
- NCIT_C74069 hasExactSynonym "Etirinotecan Pegol" @default.
- NCIT_C74069 hasExactSynonym "NKTR 102" @default.
- NCIT_C74069 hasExactSynonym "NKTR-102" @default.
- NCIT_C74069 hasExactSynonym "Onzeald" @default.
- NCIT_C74069 hasExactSynonym "PEG-Irinotecan" @default.
- NCIT_C74069 inSubset NCIT_C116977 @default.
- NCIT_C74069 inSubset NCIT_C116978 @default.
- NCIT_C74069 inSubset NCIT_C128784 @default.
- NCIT_C74069 inSubset NCIT_C157711 @default.
- NCIT_C74069 inSubset NCIT_C157712 @default.
- NCIT_C74069 inSubset NCIT_C176424 @default.
- NCIT_C74069 inSubset NCIT_C177537 @default.
- NCIT_C74069 inSubset NCIT_C63923 @default.
- NCIT_C74069 type Class @default.
- NCIT_C74069 isDefinedBy ncit.owl @default.
- NCIT_C74069 label "Etirinotecan Pegol" @default.
- NCIT_C74069 subClassOf NCIT_C129824 @default.
- NCIT_C74069 subClassOf NCIT_C129825 @default.
- NCIT_C74069 subClassOf NCIT_C1748 @default.
- NCIT_C74069 subClassOf NCIT_C1904 @default.
- NCIT_C74069 subClassOf NCIT_C1908 @default.
- NCIT_C74069 subClassOf NCIT_C1909 @default.
- NCIT_C74069 subClassOf NCIT_C2189 @default.
- NCIT_C74069 subClassOf NCIT_C274 @default.
- NCIT_C74069 subClassOf NCIT_C471 @default.
- NCIT_C74069 subClassOf NCIT_C74069 @default.