Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C74075> ?p ?o ?g. }
Showing items 1 to 48 of
48
with 100 items per page.
- NCIT_C74075 IAO_0000115 "An orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Delanzomib represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cell growth-promoting factors; and apoptotic cell death in susceptible tumor cell populations. In vitro studies indicate that this agent exhibits a favorable cytotoxicity profile toward normal human epithelial cells, bone marrow progenitors, and bone marrow-derived stromal cells relative to the proteasome inhibitor bortezomib. The intracellular protein IkappaBalpha functions as a primary inhibitor of the proinflammatory transcription factor NF-kappaB." @default.
- NCIT_C74075 NCIT_A32 NCIT_C1909 @default.
- NCIT_C74075 NCIT_A7 NCIT_C13314 @default.
- NCIT_C74075 NCIT_NHC0 "C74075" @default.
- NCIT_C74075 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C74075 NCIT_P107 "Delanzomib" @default.
- NCIT_C74075 NCIT_P108 "Delanzomib" @default.
- NCIT_C74075 NCIT_P207 "C3467895" @default.
- NCIT_C74075 NCIT_P210 "847499-27-8" @default.
- NCIT_C74075 NCIT_P319 "6IF28942WO" @default.
- NCIT_C74075 NCIT_P322 "CTRP" @default.
- NCIT_C74075 NCIT_P322 "FDA" @default.
- NCIT_C74075 NCIT_P322 "GDC" @default.
- NCIT_C74075 NCIT_P329 "583540" @default.
- NCIT_C74075 NCIT_P330 "583540" @default.
- NCIT_C74075 NCIT_P350 "C21H28BN3O5" @default.
- NCIT_C74075 NCIT_P366 "Proteasome_Inhibitor_CEP_18770" @default.
- NCIT_C74075 NCIT_P375 "Delanzomib" @default.
- NCIT_C74075 NCIT_P399 "583540" @default.
- NCIT_C74075 normalizedInformationContent "100" @default.
- NCIT_C74075 referenceCount "1" @default.
- NCIT_C74075 hasExactSynonym "((1R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpyridine-2-carboxamido)butanamido)-3-methylbutyl)boronic Acid" @default.
- NCIT_C74075 hasExactSynonym "CEP 18770" @default.
- NCIT_C74075 hasExactSynonym "CEP-18770" @default.
- NCIT_C74075 hasExactSynonym "CT-47098" @default.
- NCIT_C74075 hasExactSynonym "DELANZOMIB" @default.
- NCIT_C74075 hasExactSynonym "Delanzomib" @default.
- NCIT_C74075 hasExactSynonym "NPH-007098" @default.
- NCIT_C74075 hasExactSynonym "NPH007098" @default.
- NCIT_C74075 hasExactSynonym "Proteasome Inhibitor CEP 18770" @default.
- NCIT_C74075 inSubset NCIT_C116977 @default.
- NCIT_C74075 inSubset NCIT_C116978 @default.
- NCIT_C74075 inSubset NCIT_C128784 @default.
- NCIT_C74075 inSubset NCIT_C157711 @default.
- NCIT_C74075 inSubset NCIT_C157712 @default.
- NCIT_C74075 inSubset NCIT_C176424 @default.
- NCIT_C74075 inSubset NCIT_C177537 @default.
- NCIT_C74075 inSubset NCIT_C63923 @default.
- NCIT_C74075 type Class @default.
- NCIT_C74075 isDefinedBy ncit.owl @default.
- NCIT_C74075 label "Delanzomib" @default.
- NCIT_C74075 subClassOf NCIT_C163758 @default.
- NCIT_C74075 subClassOf NCIT_C1908 @default.
- NCIT_C74075 subClassOf NCIT_C1909 @default.
- NCIT_C74075 subClassOf NCIT_C2160 @default.
- NCIT_C74075 subClassOf NCIT_C274 @default.
- NCIT_C74075 subClassOf NCIT_C471 @default.
- NCIT_C74075 subClassOf NCIT_C74075 @default.