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- NCIT_C74077 IAO_0000115 "An orally bioavailable small molecule Src kinase inhibitor with potential antineoplastic activity. Unlike other Src kinase inhibitors which bind to the ATP-binding site, tirbanibulin specifically binds to the peptide substrate binding site of Src kinase; inhibition of kinase activity may result in the inhibition of primary tumor growth and the suppression of metastasis. Src tyrosine kinases are upregulated in many tumor cells and play important roles in tumor cell proliferation and metastasis." @default.
- NCIT_C74077 NCIT_A32 NCIT_C1909 @default.
- NCIT_C74077 NCIT_A7 NCIT_C17389 @default.
- NCIT_C74077 NCIT_NHC0 "C74077" @default.
- NCIT_C74077 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C74077 NCIT_P107 "Tirbanibulin" @default.
- NCIT_C74077 NCIT_P108 "Tirbanibulin" @default.
- NCIT_C74077 NCIT_P207 "C2348411" @default.
- NCIT_C74077 NCIT_P210 "897016-82-9" @default.
- NCIT_C74077 NCIT_P319 "4V9848RS5G" @default.
- NCIT_C74077 NCIT_P322 "CTRP" @default.
- NCIT_C74077 NCIT_P322 "FDA" @default.
- NCIT_C74077 NCIT_P322 "GDC" @default.
- NCIT_C74077 NCIT_P325 "A substance being studied in the treatment of cancer. KX2-391 blocks an enzyme needed for growth of cells and may kill cancer cells. It is a type of Src kinase inhibitor." @default.
- NCIT_C74077 NCIT_P329 "590687" @default.
- NCIT_C74077 NCIT_P330 "590687" @default.
- NCIT_C74077 NCIT_P366 "Src_Kinase_Inhibitor_KX2-391" @default.
- NCIT_C74077 NCIT_P375 "Src Kinase Inhibitor KX2-391" @default.
- NCIT_C74077 NCIT_P375 "Tirbanibulin" @default.
- NCIT_C74077 NCIT_P399 "590687" @default.
- NCIT_C74077 normalizedInformationContent "100" @default.
- NCIT_C74077 referenceCount "1" @default.
- NCIT_C74077 hasExactSynonym "2-Pyridineacetamide, 5-(4-(2-(4-Morpholinyl)ethoxy)phenyl)-n-(phenylmethyl)-" @default.
- NCIT_C74077 hasExactSynonym "KX01" @default.
- NCIT_C74077 hasExactSynonym "KX2-391" @default.
- NCIT_C74077 hasExactSynonym "TIRBANIBULIN" @default.
- NCIT_C74077 hasExactSynonym "Tirbanibulin" @default.
- NCIT_C74077 inSubset NCIT_C116977 @default.
- NCIT_C74077 inSubset NCIT_C116978 @default.
- NCIT_C74077 inSubset NCIT_C128784 @default.
- NCIT_C74077 inSubset NCIT_C157711 @default.
- NCIT_C74077 inSubset NCIT_C157712 @default.
- NCIT_C74077 inSubset NCIT_C176424 @default.
- NCIT_C74077 inSubset NCIT_C177537 @default.
- NCIT_C74077 inSubset NCIT_C63923 @default.
- NCIT_C74077 type Class @default.
- NCIT_C74077 isDefinedBy ncit.owl @default.
- NCIT_C74077 label "Tirbanibulin" @default.
- NCIT_C74077 subClassOf NCIT_C129824 @default.
- NCIT_C74077 subClassOf NCIT_C129825 @default.
- NCIT_C74077 subClassOf NCIT_C1404 @default.
- NCIT_C74077 subClassOf NCIT_C1908 @default.
- NCIT_C74077 subClassOf NCIT_C1909 @default.
- NCIT_C74077 subClassOf NCIT_C1967 @default.
- NCIT_C74077 subClassOf NCIT_C2189 @default.
- NCIT_C74077 subClassOf NCIT_C274 @default.
- NCIT_C74077 subClassOf NCIT_C471 @default.
- NCIT_C74077 subClassOf NCIT_C74077 @default.