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- NCIT_C74089 IAO_0000115 "A highly tumor-selective vaccinia virus (vv) with an engineered double deletion (DD) of the thymidine kinase (tk) and vaccinia growth factor genes and additions of both a cytosine deaminase (CD) gene and a somatostatin receptor (SR) gene with potential oncolytic viral activity. The tk and vaccinia growth factor gene deletions in intratumorally administered vaccinia virus (vvDD-CDSR) help to restrict its replication and cytolytic activity to tumor cells with large nucleotide pools and tumor cells with activation of the EGFR-Ras pathway. Addition of the CD gene to the viral genome allows control of oncolytic viral infection through the administration of the prodrug 5-fluorocytosine (5-FC), converted by CD to the antimetabolite 5-fluorouracil (5-FU) in cells infected with this agent. Addition of the SR gene allows anatomical localization of vaccinia virus (vvDD-CDSR) through the use of octreotide scintigraphy." @default.
- NCIT_C74089 NCIT_NHC0 "C74089" @default.
- NCIT_C74089 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C74089 NCIT_P107 "Vaccinia Virus DD-CDSR" @default.
- NCIT_C74089 NCIT_P108 "Vaccinia Virus DD-CDSR" @default.
- NCIT_C74089 NCIT_P208 "CL384004" @default.
- NCIT_C74089 NCIT_P322 "CTRP" @default.
- NCIT_C74089 NCIT_P329 "583659" @default.
- NCIT_C74089 NCIT_P330 "583659" @default.
- NCIT_C74089 NCIT_P366 "Vaccinia_virus_DD-CDSR_Vaccine" @default.
- NCIT_C74089 NCIT_P399 "583659" @default.
- NCIT_C74089 normalizedInformationContent "100" @default.
- NCIT_C74089 referenceCount "1" @default.
- NCIT_C74089 hasExactSynonym "Vaccinia Virus (vvDD-CDSR)" @default.
- NCIT_C74089 hasExactSynonym "Vaccinia Virus DD-CDSR" @default.
- NCIT_C74089 hasExactSynonym "vvDD-CDSR" @default.
- NCIT_C74089 inSubset NCIT_C116977 @default.
- NCIT_C74089 inSubset NCIT_C116978 @default.
- NCIT_C74089 inSubset NCIT_C128784 @default.
- NCIT_C74089 inSubset NCIT_C176424 @default.
- NCIT_C74089 type Class @default.
- NCIT_C74089 isDefinedBy ncit.owl @default.
- NCIT_C74089 label "Vaccinia Virus DD-CDSR" @default.
- NCIT_C74089 subClassOf NCIT_C1572 @default.
- NCIT_C74089 subClassOf NCIT_C1908 @default.
- NCIT_C74089 subClassOf NCIT_C1909 @default.
- NCIT_C74089 subClassOf NCIT_C1962 @default.
- NCIT_C74089 subClassOf NCIT_C2313 @default.
- NCIT_C74089 subClassOf NCIT_C307 @default.
- NCIT_C74089 subClassOf NCIT_C308 @default.
- NCIT_C74089 subClassOf NCIT_C74089 @default.
- NCIT_C74089 subClassOf NCIT_C923 @default.
- NCIT_C74089 subClassOf NCIT_C96404 @default.