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- NCIT_C74270 IAO_0000115 "A long-acting, synthetic nonapeptide analog of gonadotropin-releasing hormone (GnRH) with potential anti-tumor activity. Upon administration, histrelin binds to and activates GnRH receptors; prolonged administration results in pituitary GnRH receptor desensitization and inhibition of follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion, leading to a significant decline in testosterone production in males and may inhibit androgen receptor-positive tumor progression; in females, prolonged administration results in decreased estradiol production." @default.
- NCIT_C74270 NCIT_A5 NCIT_C77424 @default.
- NCIT_C74270 NCIT_A7 NCIT_C38910 @default.
- NCIT_C74270 NCIT_NHC0 "C74270" @default.
- NCIT_C74270 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C74270 NCIT_P107 "Histrelin" @default.
- NCIT_C74270 NCIT_P108 "Histrelin" @default.
- NCIT_C74270 NCIT_P207 "C0121902" @default.
- NCIT_C74270 NCIT_P210 "76712-82-8" @default.
- NCIT_C74270 NCIT_P319 "H50H3S3W74" @default.
- NCIT_C74270 NCIT_P322 "CTRP" @default.
- NCIT_C74270 NCIT_P322 "FDA" @default.
- NCIT_C74270 NCIT_P322 "OORO" @default.
- NCIT_C74270 NCIT_P350 "C66H86N18O12" @default.
- NCIT_C74270 NCIT_P366 "Histrelin" @default.
- NCIT_C74270 NCIT_P368 "CHEBI:5739" @default.
- NCIT_C74270 normalizedInformationContent "100" @default.
- NCIT_C74270 referenceCount "1" @default.
- NCIT_C74270 hasExactSynonym "HISTRELIN" @default.
- NCIT_C74270 hasExactSynonym "Histrelin" @default.
- NCIT_C74270 inSubset NCIT_C116977 @default.
- NCIT_C74270 inSubset NCIT_C116978 @default.
- NCIT_C74270 inSubset NCIT_C192234 @default.
- NCIT_C74270 inSubset NCIT_C63923 @default.
- NCIT_C74270 type Class @default.
- NCIT_C74270 isDefinedBy ncit.owl @default.
- NCIT_C74270 label "Histrelin" @default.
- NCIT_C74270 subClassOf NCIT_C147908 @default.
- NCIT_C74270 subClassOf NCIT_C1908 @default.
- NCIT_C74270 subClassOf NCIT_C1909 @default.
- NCIT_C74270 subClassOf NCIT_C1910 @default.
- NCIT_C74270 subClassOf NCIT_C548 @default.
- NCIT_C74270 subClassOf NCIT_C74270 @default.