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- NCIT_C749 IAO_0000115 "The sodium salt of piperacillin, a broad-spectrum semisynthetic, ampicillin-derived ureidopenicillin antibiotic with bactericidal activity. Piperacillin binds to and inactivates penicillin-binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the weakening of the bacterial cell wall and cell lysis. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity." @default.
- NCIT_C749 NCIT_A6 NCIT_C62069 @default.
- NCIT_C749 NCIT_NHC0 "C749" @default.
- NCIT_C749 NCIT_P106 "Antibiotic" @default.
- NCIT_C749 NCIT_P106 "Organic Chemical" @default.
- NCIT_C749 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C749 NCIT_P108 "Piperacillin Sodium" @default.
- NCIT_C749 NCIT_P207 "C0700463" @default.
- NCIT_C749 NCIT_P210 "59703-84-3" @default.
- NCIT_C749 NCIT_P319 "M98T69Q7HP" @default.
- NCIT_C749 NCIT_P322 "FDA" @default.
- NCIT_C749 NCIT_P329 "39555" @default.
- NCIT_C749 NCIT_P330 "39555" @default.
- NCIT_C749 NCIT_P350 "C23H26N5O7S.Na" @default.
- NCIT_C749 NCIT_P366 "Piperacillin" @default.
- NCIT_C749 NCIT_P368 "CHEBI:8233" @default.
- NCIT_C749 NCIT_P399 "39555" @default.
- NCIT_C749 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C749 referenceCount "3" @default.
- NCIT_C749 hasExactSynonym "CL 227, 193" @default.
- NCIT_C749 hasExactSynonym "PIPERACILLIN SODIUM" @default.
- NCIT_C749 hasExactSynonym "Piperacillin Sodium" @default.
- NCIT_C749 hasExactSynonym "Pipracil" @default.
- NCIT_C749 hasExactSynonym "Sodium (2S,5R,6R)-6-((R)-2-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate" @default.
- NCIT_C749 hasExactSynonym "T-1220" @default.
- NCIT_C749 inSubset NCIT_C176424 @default.
- NCIT_C749 inSubset NCIT_C63923 @default.
- NCIT_C749 type Class @default.
- NCIT_C749 isDefinedBy ncit.owl @default.
- NCIT_C749 label "Piperacillin Sodium" @default.
- NCIT_C749 subClassOf NCIT_C1500 @default.
- NCIT_C749 subClassOf NCIT_C1558 @default.
- NCIT_C749 subClassOf NCIT_C1908 @default.
- NCIT_C749 subClassOf NCIT_C1909 @default.
- NCIT_C749 subClassOf NCIT_C254 @default.
- NCIT_C749 subClassOf NCIT_C258 @default.
- NCIT_C749 subClassOf NCIT_C260 @default.
- NCIT_C749 subClassOf NCIT_C749 @default.