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- NCIT_C74960 IAO_0000115 "The orally bioavailable alpha form of the naturally-occurring fat-soluble vitamin E, with potent antioxidant and cytoprotective activities. Upon administration, alpha-tocopherol neutralizes free radicals, thereby protecting tissues and organs from oxidative damage. Alpha-tocopherol gets incorporated into biological membranes, prevents protein oxidation and inhibits lipid peroxidation, thereby maintaining cell membrane integrity and protecting the cell against damage. In addition, alpha-tocopherol inhibits the activity of protein kinase C (PKC) and PKC-mediated pathways. Alpha-tocopherol also modulates the expression of various genes, plays a key role in neurological function, inhibits platelet aggregation and enhances vasodilation. Compared with other forms of tocopherol, alpha-tocopherol is the most biologically active form and is the form that is preferentially absorbed and retained in the body." @default.
- NCIT_C74960 NCIT_NHC0 "C74960" @default.
- NCIT_C74960 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C74960 NCIT_P106 "Vitamin" @default.
- NCIT_C74960 NCIT_P107 "Alpha-Tocopherol" @default.
- NCIT_C74960 NCIT_P108 "Alpha-Tocopherol" @default.
- NCIT_C74960 NCIT_P208 "CL938214" @default.
- NCIT_C74960 NCIT_P210 "59-02-9" @default.
- NCIT_C74960 NCIT_P319 "H4N855PNZ1" @default.
- NCIT_C74960 NCIT_P322 "CRCH" @default.
- NCIT_C74960 NCIT_P322 "CTRP" @default.
- NCIT_C74960 NCIT_P322 "FDA" @default.
- NCIT_C74960 NCIT_P325 "Tocopherol with three methyl groups on its chromanol ring." @default.
- NCIT_C74960 NCIT_P329 "775583" @default.
- NCIT_C74960 NCIT_P330 "775583" @default.
- NCIT_C74960 NCIT_P350 "C29H50O2" @default.
- NCIT_C74960 NCIT_P353 "TOCPHA" @default.
- NCIT_C74960 NCIT_P354 "323" @default.
- NCIT_C74960 NCIT_P355 "mg" @default.
- NCIT_C74960 NCIT_P358 "Y" @default.
- NCIT_C74960 NCIT_P360 "Y" @default.
- NCIT_C74960 NCIT_P366 "Alpha-Tocopherol" @default.
- NCIT_C74960 NCIT_P368 "CHEBI:18145" @default.
- NCIT_C74960 NCIT_P399 "775583" @default.
- NCIT_C74960 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C74960 referenceCount "3" @default.
- NCIT_C74960 hasExactSynonym ".ALPHA.-TOCOPHEROL" @default.
- NCIT_C74960 hasExactSynonym "2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol" @default.
- NCIT_C74960 hasExactSynonym "3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol" @default.
- NCIT_C74960 hasExactSynonym "Alpha-Tocopherol" @default.
- NCIT_C74960 hasExactSynonym "Alpha-tocopherol" @default.
- NCIT_C74960 inSubset NCIT_C116977 @default.
- NCIT_C74960 inSubset NCIT_C142799 @default.
- NCIT_C74960 inSubset NCIT_C176424 @default.
- NCIT_C74960 inSubset NCIT_C63923 @default.
- NCIT_C74960 type Class @default.
- NCIT_C74960 isDefinedBy ncit.owl @default.
- NCIT_C74960 label "Alpha-Tocopherol" @default.
- NCIT_C74960 subClassOf NCIT_C1908 @default.
- NCIT_C74960 subClassOf NCIT_C1930 @default.
- NCIT_C74960 subClassOf NCIT_C1949 @default.
- NCIT_C74960 subClassOf NCIT_C54060 @default.
- NCIT_C74960 subClassOf NCIT_C68313 @default.
- NCIT_C74960 subClassOf NCIT_C74960 @default.