Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C75029> ?p ?o ?g. }
Showing items 1 to 35 of
35
with 100 items per page.
- NCIT_C75029 IAO_0000115 "An orally active, non-competitive, and selective alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor antagonist, with anti-epileptic activity. Although the mechanism of action through which perampanel exerts its antiepileptic effect has not been fully elucidated, this agent antagonizes the AMPA subtype of the excitatory glutamate receptor found on postsynaptic neurons in the central nervous system (CNS). This antagonistic action prevents AMPA receptor activation by glutamate and results in the inhibition of neuronal excitation, repetitive neuronal firing, and the stabilization of hyper-excited neural membranes. Glutamate, the primary excitatory neurotransmitter in the CNS, plays an important role in various neurological disorders caused by neuronal hyperexcitation." @default.
- NCIT_C75029 NCIT_NHC0 "C75029" @default.
- NCIT_C75029 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C75029 NCIT_P107 "Perampanel" @default.
- NCIT_C75029 NCIT_P108 "Perampanel" @default.
- NCIT_C75029 NCIT_P207 "C2698764" @default.
- NCIT_C75029 NCIT_P210 "380917-97-5" @default.
- NCIT_C75029 NCIT_P319 "H821664NPK" @default.
- NCIT_C75029 NCIT_P322 "CTRP" @default.
- NCIT_C75029 NCIT_P322 "FDA" @default.
- NCIT_C75029 NCIT_P329 "769461" @default.
- NCIT_C75029 NCIT_P330 "769461" @default.
- NCIT_C75029 NCIT_P350 "C23H15N3O" @default.
- NCIT_C75029 NCIT_P366 "Perampanel" @default.
- NCIT_C75029 NCIT_P399 "769461" @default.
- NCIT_C75029 normalizedInformationContent "100" @default.
- NCIT_C75029 referenceCount "1" @default.
- NCIT_C75029 hasExactSynonym "3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one" @default.
- NCIT_C75029 hasExactSynonym "Benzonitrile, 2-(1',6'-Dihydro-6'-oxo-1'-phenyl(2,3'-bipyridin)-5'-yl)-" @default.
- NCIT_C75029 hasExactSynonym "E2007" @default.
- NCIT_C75029 hasExactSynonym "Fycompa" @default.
- NCIT_C75029 hasExactSynonym "PERAMPANEL" @default.
- NCIT_C75029 hasExactSynonym "Perampanel" @default.
- NCIT_C75029 inSubset NCIT_C116977 @default.
- NCIT_C75029 inSubset NCIT_C116978 @default.
- NCIT_C75029 inSubset NCIT_C176424 @default.
- NCIT_C75029 inSubset NCIT_C63923 @default.
- NCIT_C75029 type Class @default.
- NCIT_C75029 isDefinedBy ncit.owl @default.
- NCIT_C75029 label "Perampanel" @default.
- NCIT_C75029 subClassOf NCIT_C1908 @default.
- NCIT_C75029 subClassOf NCIT_C1909 @default.
- NCIT_C75029 subClassOf NCIT_C47795 @default.
- NCIT_C75029 subClassOf NCIT_C75029 @default.
- NCIT_C75029 subClassOf NCIT_C78272 @default.