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- NCIT_C751 IAO_0000115 "A nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties. As a non-selective, nonsteroidal anti-inflammatory drug (NSAID), piroxicam binds and chelates both isoforms of cyclooxygenases (COX1 and COX2), thereby stalling phospholipase A2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects." @default.
- NCIT_C751 NCIT_NHC0 "C751" @default.
- NCIT_C751 NCIT_P106 "Organic Chemical" @default.
- NCIT_C751 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C751 NCIT_P108 "Piroxicam" @default.
- NCIT_C751 NCIT_P175 "666076" @default.
- NCIT_C751 NCIT_P207 "C0031990" @default.
- NCIT_C751 NCIT_P210 "36322-90-4" @default.
- NCIT_C751 NCIT_P319 "13T4O6VMAM" @default.
- NCIT_C751 NCIT_P322 "FDA" @default.
- NCIT_C751 NCIT_P329 "39761" @default.
- NCIT_C751 NCIT_P330 "39761" @default.
- NCIT_C751 NCIT_P350 "C15H13N3O4S" @default.
- NCIT_C751 NCIT_P366 "Piroxicam" @default.
- NCIT_C751 NCIT_P368 "CHEBI:8249" @default.
- NCIT_C751 NCIT_P399 "39761" @default.
- NCIT_C751 NCIT_R122 NCIT_C16484 @default.
- NCIT_C751 NCIT_R122 NCIT_C16486 @default.
- NCIT_C751 NCIT_R122 NCIT_C16554 @default.
- NCIT_C751 NCIT_R122 NCIT_C16865 @default.
- NCIT_C751 NCIT_R122 NCIT_C16946 @default.
- NCIT_C751 NCIT_R122 NCIT_C17021 @default.
- NCIT_C751 NCIT_R122 NCIT_C20027 @default.
- NCIT_C751 NCIT_R122 NCIT_C26548 @default.
- NCIT_C751 NCIT_R122 NCIT_C28459 @default.
- NCIT_C751 NCIT_R122 NCIT_C28750 @default.
- NCIT_C751 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C751 referenceCount "3" @default.
- NCIT_C751 hasExactSynonym "4-Hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboximide-1,1-dioxide" @default.
- NCIT_C751 hasExactSynonym "Feldene" @default.
- NCIT_C751 hasExactSynonym "PIROXICAM" @default.
- NCIT_C751 hasExactSynonym "PXM" @default.
- NCIT_C751 hasExactSynonym "Piroxicam" @default.
- NCIT_C751 inSubset NCIT_C176424 @default.
- NCIT_C751 inSubset NCIT_C63923 @default.
- NCIT_C751 type Class @default.
- NCIT_C751 isDefinedBy ncit.owl @default.
- NCIT_C751 label "Piroxicam" @default.
- NCIT_C751 subClassOf B6ce91d7f90bb013ea3014948f3c21e52 @default.
- NCIT_C751 subClassOf B85059139655db48569e3408f81d7af49 @default.
- NCIT_C751 subClassOf NCIT_C1323 @default.
- NCIT_C751 subClassOf NCIT_C1908 @default.
- NCIT_C751 subClassOf NCIT_C1909 @default.
- NCIT_C751 subClassOf NCIT_C1913 @default.
- NCIT_C751 subClassOf NCIT_C1915 @default.
- NCIT_C751 subClassOf NCIT_C1933 @default.
- NCIT_C751 subClassOf NCIT_C2198 @default.
- NCIT_C751 subClassOf NCIT_C2356 @default.
- NCIT_C751 subClassOf NCIT_C241 @default.
- NCIT_C751 subClassOf NCIT_C257 @default.
- NCIT_C751 subClassOf NCIT_C471 @default.
- NCIT_C751 subClassOf NCIT_C718 @default.
- NCIT_C751 subClassOf NCIT_C751 @default.
- NCIT_C751 subClassOf NCIT_C78272 @default.