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- NCIT_C75110 IAO_0000115 "A medoxomil prodrug of azilsartan, an angiotensin II receptor antagonist with antihypertensive activity. Upon hydrolysis, azilsartan selectively and competitively binds to the AT1 subtype angiotensin II receptor and blocks the binding of angiotensin II to the receptor, thus promoting vasodilatation and counteracting the effects of aldosterone. Converted from angiotensin I by angiotensin-converting enzyme (ACE), angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, decreasing sodium excretion and increasing potassium excretion, and acts as a vasoconstrictor in vascular smooth muscle." @default.
- NCIT_C75110 NCIT_A5 NCIT_C75108 @default.
- NCIT_C75110 NCIT_NHC0 "C75110" @default.
- NCIT_C75110 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C75110 NCIT_P108 "Azilsartan Medoxomil" @default.
- NCIT_C75110 NCIT_P207 "C2698291" @default.
- NCIT_C75110 NCIT_P210 "863031-21-4" @default.
- NCIT_C75110 NCIT_P302 "Hypertension" @default.
- NCIT_C75110 NCIT_P319 "LL0G25K7I2" @default.
- NCIT_C75110 NCIT_P322 "FDA" @default.
- NCIT_C75110 NCIT_P350 "C30H24N4O8" @default.
- NCIT_C75110 NCIT_P366 "Azilsartan_Medoxomil" @default.
- NCIT_C75110 normalizedInformationContent "100" @default.
- NCIT_C75110 referenceCount "1" @default.
- NCIT_C75110 hasExactSynonym "(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4- oxadiazol-3-yl)biphenyl-2-yl)methyl)-1H-benzo(d)imidazole-7-carboxylate" @default.
- NCIT_C75110 hasExactSynonym "AZILSARTAN MEDOXOMIL" @default.
- NCIT_C75110 hasExactSynonym "Azilsartan Medoxomil" @default.
- NCIT_C75110 hasExactSynonym "Edarbi" @default.
- NCIT_C75110 hasExactSynonym "TAK-491" @default.
- NCIT_C75110 inSubset NCIT_C63923 @default.
- NCIT_C75110 type Class @default.
- NCIT_C75110 isDefinedBy ncit.owl @default.
- NCIT_C75110 label "Azilsartan Medoxomil" @default.
- NCIT_C75110 subClassOf NCIT_C1908 @default.
- NCIT_C75110 subClassOf NCIT_C1909 @default.
- NCIT_C75110 subClassOf NCIT_C270 @default.
- NCIT_C75110 subClassOf NCIT_C66930 @default.
- NCIT_C75110 subClassOf NCIT_C75110 @default.
- NCIT_C75110 subClassOf NCIT_C78274 @default.