Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C75927> ?p ?o ?g. }
Showing items 1 to 26 of
26
with 100 items per page.
- NCIT_C75927 IAO_0000115 "The active metabolite of cilazapril, a pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow." @default.
- NCIT_C75927 NCIT_NHC0 "C75927" @default.
- NCIT_C75927 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C75927 NCIT_P108 "Cilazaprilat" @default.
- NCIT_C75927 NCIT_P207 "C0055724" @default.
- NCIT_C75927 NCIT_P210 "90139-06-3" @default.
- NCIT_C75927 NCIT_P319 "WBL76FH528" @default.
- NCIT_C75927 NCIT_P322 "FDA" @default.
- NCIT_C75927 NCIT_P350 "C20H27N3O5" @default.
- NCIT_C75927 NCIT_P366 "Cilazaprilat" @default.
- NCIT_C75927 normalizedInformationContent "100" @default.
- NCIT_C75927 referenceCount "1" @default.
- NCIT_C75927 hasExactSynonym "CILAZAPRILAT" @default.
- NCIT_C75927 hasExactSynonym "Cilazaprilat" @default.
- NCIT_C75927 inSubset NCIT_C63923 @default.
- NCIT_C75927 type Class @default.
- NCIT_C75927 isDefinedBy ncit.owl @default.
- NCIT_C75927 label "Cilazaprilat" @default.
- NCIT_C75927 subClassOf NCIT_C1908 @default.
- NCIT_C75927 subClassOf NCIT_C1909 @default.
- NCIT_C75927 subClassOf NCIT_C247 @default.
- NCIT_C75927 subClassOf NCIT_C270 @default.
- NCIT_C75927 subClassOf NCIT_C471 @default.
- NCIT_C75927 subClassOf NCIT_C75927 @default.
- NCIT_C75927 subClassOf NCIT_C78274 @default.
- NCIT_C75927 subClassOf NCIT_C783 @default.