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- NCIT_C76133 IAO_0000115 "A pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow." @default.
- NCIT_C76133 NCIT_NHC0 "C76133" @default.
- NCIT_C76133 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C76133 NCIT_P108 "Cilazapril Monohydrate" @default.
- NCIT_C76133 NCIT_P207 "C0055723" @default.
- NCIT_C76133 NCIT_P210 "92077-78-6" @default.
- NCIT_C76133 NCIT_P319 "19KW7PI29F" @default.
- NCIT_C76133 NCIT_P322 "FDA" @default.
- NCIT_C76133 NCIT_P350 "C22H31N3O5.H2O" @default.
- NCIT_C76133 NCIT_P366 "Cilazapril" @default.
- NCIT_C76133 normalizedInformationContent "100" @default.
- NCIT_C76133 referenceCount "1" @default.
- NCIT_C76133 hasExactSynonym "(1S,9S)-9-(((S)-1-Carboxy-3-phenylpropyl)amino)octahydro-10-oxo-6H-pyridazino(1,2-a)(1,2)diazepine-1-carboxylic Acid 9-ethyl Ester Monohydrate" @default.
- NCIT_C76133 hasExactSynonym "CILAZAPRIL" @default.
- NCIT_C76133 hasExactSynonym "Cilazapril Monohydrate" @default.
- NCIT_C76133 hasExactSynonym "Cilazapril" @default.
- NCIT_C76133 hasExactSynonym "Ro 31-2848 Monohydrate" @default.
- NCIT_C76133 inSubset NCIT_C63923 @default.
- NCIT_C76133 type Class @default.
- NCIT_C76133 isDefinedBy ncit.owl @default.
- NCIT_C76133 label "Cilazapril Monohydrate" @default.
- NCIT_C76133 subClassOf NCIT_C1908 @default.
- NCIT_C76133 subClassOf NCIT_C1909 @default.
- NCIT_C76133 subClassOf NCIT_C247 @default.
- NCIT_C76133 subClassOf NCIT_C270 @default.
- NCIT_C76133 subClassOf NCIT_C471 @default.
- NCIT_C76133 subClassOf NCIT_C76133 @default.
- NCIT_C76133 subClassOf NCIT_C78274 @default.
- NCIT_C76133 subClassOf NCIT_C783 @default.