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- NCIT_C76134 IAO_0000115 "The anhydrous form of the pyridazine angiotensin-converting enzyme (ACE) inhibitor cilazapril with antihypertensive activity. As a prodrug cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow." @default.
- NCIT_C76134 NCIT_NHC0 "C76134" @default.
- NCIT_C76134 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C76134 NCIT_P108 "Cilazapril Anhydrous" @default.
- NCIT_C76134 NCIT_P207 "C0886706" @default.
- NCIT_C76134 NCIT_P210 "88768-40-5" @default.
- NCIT_C76134 NCIT_P319 "8Q9454114Q" @default.
- NCIT_C76134 NCIT_P322 "FDA" @default.
- NCIT_C76134 NCIT_P350 "C22H31N3O5" @default.
- NCIT_C76134 NCIT_P366 "Cilazapril_Anhydrous" @default.
- NCIT_C76134 normalizedInformationContent "100" @default.
- NCIT_C76134 referenceCount "1" @default.
- NCIT_C76134 hasExactSynonym "CILAZAPRIL ANHYDROUS" @default.
- NCIT_C76134 hasExactSynonym "Cilazapril Anhydrous" @default.
- NCIT_C76134 inSubset NCIT_C63923 @default.
- NCIT_C76134 type Class @default.
- NCIT_C76134 isDefinedBy ncit.owl @default.
- NCIT_C76134 label "Cilazapril Anhydrous" @default.
- NCIT_C76134 subClassOf NCIT_C1908 @default.
- NCIT_C76134 subClassOf NCIT_C1909 @default.
- NCIT_C76134 subClassOf NCIT_C247 @default.
- NCIT_C76134 subClassOf NCIT_C270 @default.
- NCIT_C76134 subClassOf NCIT_C471 @default.
- NCIT_C76134 subClassOf NCIT_C76134 @default.
- NCIT_C76134 subClassOf NCIT_C78274 @default.
- NCIT_C76134 subClassOf NCIT_C783 @default.