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- NCIT_C76159 IAO_0000115 "The cephem double ester prodrug of cefcanel, a semisynthetic third-generation cephalosporin with antibacterial activity. Cefcanel daloxate is hydrolyzed in the intestinal lumen and in the gut wall by esterases to form the active metabolite cefcanel. Cefcanel binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." @default.
- NCIT_C76159 NCIT_NHC0 "C76159" @default.
- NCIT_C76159 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C76159 NCIT_P108 "Cefcanel Daloxate" @default.
- NCIT_C76159 NCIT_P207 "C0064447" @default.
- NCIT_C76159 NCIT_P210 "97275-40-6" @default.
- NCIT_C76159 NCIT_P319 "D9693UHF82" @default.
- NCIT_C76159 NCIT_P322 "FDA" @default.
- NCIT_C76159 NCIT_P350 "C27H27N5O9S3" @default.
- NCIT_C76159 NCIT_P366 "Cefcanel_Daloxate" @default.
- NCIT_C76159 normalizedInformationContent "100" @default.
- NCIT_C76159 referenceCount "1" @default.
- NCIT_C76159 hasExactSynonym "CEFCANEL DALOXATE" @default.
- NCIT_C76159 hasExactSynonym "Cefcanel Daloxate" @default.
- NCIT_C76159 inSubset NCIT_C63923 @default.
- NCIT_C76159 type Class @default.
- NCIT_C76159 isDefinedBy ncit.owl @default.
- NCIT_C76159 label "Cefcanel Daloxate" @default.
- NCIT_C76159 subClassOf NCIT_C1908 @default.
- NCIT_C76159 subClassOf NCIT_C1909 @default.
- NCIT_C76159 subClassOf NCIT_C254 @default.
- NCIT_C76159 subClassOf NCIT_C258 @default.
- NCIT_C76159 subClassOf NCIT_C260 @default.
- NCIT_C76159 subClassOf NCIT_C357 @default.
- NCIT_C76159 subClassOf NCIT_C76159 @default.