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- NCIT_C76199 IAO_0000115 "A benzimidazole-quinolinone compound and receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Dovitinib binds to and inhibits the phosphorylation of type III-V RTKs, such as vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) that promote tumor cell proliferation and survival in certain cancer cells. In addition, this agent also inhibits other members of the RTK superfamily, including fibroblast growth factor receptor 1 and 3, FMS-like tyrosine kinase 3, stem cell factor receptor (c-KIT), and colony stimulating factor receptor 1. This may further lead to a reduction of cellular proliferation and angiogenesis, and an induction of tumor cell apoptosis." @default.
- NCIT_C76199 NCIT_A32 NCIT_C1909 @default.
- NCIT_C76199 NCIT_A5 NCIT_C62435 @default.
- NCIT_C76199 NCIT_A7 NCIT_C17293 @default.
- NCIT_C76199 NCIT_A7 NCIT_C17322 @default.
- NCIT_C76199 NCIT_A7 NCIT_C17328 @default.
- NCIT_C76199 NCIT_A7 NCIT_C17392 @default.
- NCIT_C76199 NCIT_A7 NCIT_C17590 @default.
- NCIT_C76199 NCIT_A7 NCIT_C26129 @default.
- NCIT_C76199 NCIT_NHC0 "C76199" @default.
- NCIT_C76199 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C76199 NCIT_P107 "Dovitinib" @default.
- NCIT_C76199 NCIT_P108 "Dovitinib" @default.
- NCIT_C76199 NCIT_P207 "C2699806" @default.
- NCIT_C76199 NCIT_P210 "405169-16-6" @default.
- NCIT_C76199 NCIT_P319 "I35H55G906" @default.
- NCIT_C76199 NCIT_P322 "CTRP" @default.
- NCIT_C76199 NCIT_P322 "FDA" @default.
- NCIT_C76199 NCIT_P322 "GDC" @default.
- NCIT_C76199 NCIT_P350 "C21H21FN6O" @default.
- NCIT_C76199 NCIT_P366 "Dovitinib" @default.
- NCIT_C76199 NCIT_P375 "Dovitinib" @default.
- NCIT_C76199 normalizedInformationContent "100" @default.
- NCIT_C76199 referenceCount "1" @default.
- NCIT_C76199 hasExactSynonym "DOVITINIB" @default.
- NCIT_C76199 hasExactSynonym "Dovitinib" @default.
- NCIT_C76199 inSubset NCIT_C116977 @default.
- NCIT_C76199 inSubset NCIT_C116978 @default.
- NCIT_C76199 inSubset NCIT_C128784 @default.
- NCIT_C76199 inSubset NCIT_C157711 @default.
- NCIT_C76199 inSubset NCIT_C157712 @default.
- NCIT_C76199 inSubset NCIT_C177537 @default.
- NCIT_C76199 inSubset NCIT_C63923 @default.
- NCIT_C76199 type Class @default.
- NCIT_C76199 isDefinedBy ncit.owl @default.
- NCIT_C76199 label "Dovitinib" @default.
- NCIT_C76199 subClassOf NCIT_C129824 @default.
- NCIT_C76199 subClassOf NCIT_C129825 @default.
- NCIT_C76199 subClassOf NCIT_C1404 @default.
- NCIT_C76199 subClassOf NCIT_C1908 @default.
- NCIT_C76199 subClassOf NCIT_C1909 @default.
- NCIT_C76199 subClassOf NCIT_C1967 @default.
- NCIT_C76199 subClassOf NCIT_C2189 @default.
- NCIT_C76199 subClassOf NCIT_C274 @default.
- NCIT_C76199 subClassOf NCIT_C471 @default.
- NCIT_C76199 subClassOf NCIT_C76199 @default.