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- NCIT_C76405 IAO_0000115 "A non-peptide tyrosine derivative, with anticoagulant activity. Upon administration, tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. This prevents the GP IIb/IIIa receptor complex-mediated activation of adenylyl cyclase. This results in decreased levels of cAMP, interferes with the platelet membrane function and subsequent platelet-platelet interaction, prevents the release of platelet granule constituents and prolongs bleeding time." @default.
- NCIT_C76405 NCIT_A5 NCIT_C47759 @default.
- NCIT_C76405 NCIT_NHC0 "C76405" @default.
- NCIT_C76405 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C76405 NCIT_P108 "Tirofiban" @default.
- NCIT_C76405 NCIT_P207 "C0247025" @default.
- NCIT_C76405 NCIT_P210 "144494-65-5" @default.
- NCIT_C76405 NCIT_P319 "GGX234SI5H" @default.
- NCIT_C76405 NCIT_P322 "FDA" @default.
- NCIT_C76405 NCIT_P350 "C22H36N2O5S" @default.
- NCIT_C76405 NCIT_P366 "Tirofiban" @default.
- NCIT_C76405 NCIT_P368 "CHEBI:9605" @default.
- NCIT_C76405 normalizedInformationContent "100" @default.
- NCIT_C76405 referenceCount "1" @default.
- NCIT_C76405 hasExactSynonym "TIROFIBAN" @default.
- NCIT_C76405 hasExactSynonym "Tirofiban" @default.
- NCIT_C76405 inSubset NCIT_C173381 @default.
- NCIT_C76405 inSubset NCIT_C173383 @default.
- NCIT_C76405 inSubset NCIT_C63923 @default.
- NCIT_C76405 type Class @default.
- NCIT_C76405 isDefinedBy ncit.owl @default.
- NCIT_C76405 label "Tirofiban" @default.
- NCIT_C76405 subClassOf NCIT_C1327 @default.
- NCIT_C76405 subClassOf NCIT_C1908 @default.
- NCIT_C76405 subClassOf NCIT_C1909 @default.
- NCIT_C76405 subClassOf NCIT_C76405 @default.
- NCIT_C76405 subClassOf NCIT_C78275 @default.